M182
MDL-12,330A 盐酸盐
≥98% (HPLC), Adenylyl cyclase inhibitor, powder
别名:
顺式-N-（2-苯基环戊基）-氮杂环十三碳-1-烯-2-胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C23H36N2 · HCl
化学文摘社编号:
分子量:
377.01
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
MDL-12,330A 盐酸盐, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
Cl[H].C1CCCCCN=C(CCCCC1)N[C@H]2CCC[C@H]2c3ccccc3
InChI
1S/C23H36N2.ClH/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20;/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25);1H/t21-,22-;/m0./s1
InChI key
CKOPQUCSDBVAQG-VROPFNGYSA-N
相关类别
Application
MDL-12,330A盐酸盐已用作腺苷酸环化酶抑制剂，抑制间充质干细胞(MSC)中的环磷腺苷信号传导。它也已用作腺苷酸环化酶抑制剂，检测其对悬尾实验(TST)小鼠自主活动的影响。
Biochem/physiol Actions
MDL-12,330A是一种环烷基内亚胺(lactamimide)，可用作电压门控钾离子通道阻断剂(KV)，有助于动作电位时程(APD)延长和胰岛素分泌。它也可阻断钙(Ca2+)内流通道。
腺苷酸环化酶抑制剂。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Major depressive disorder (MDD) is highly comorbid with anxiety disorders. It has been reported that the bed nucleus of the stria terminalis (BNST) is important for the induction of anxiety and MDD. Recently, the Gαq protein signaling within the BNST
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This study describes a unique function of taurocholate in bile canalicular formation involving signaling through a cAMP-Epac-MEK-Rap1-LKB1-AMPK pathway. In rat hepatocyte sandwich cultures, polarization was manifested by sequential progression of bile canaliculi from small structures to a fully branched network.
Gillian P Johnson et al.
Journal of cell science, 131(21) (2018-10-12)
Mechanical loading is a potent stimulus of bone adaptation, requiring the replenishment of the osteoblast from a progenitor population. One such progenitor is the mesenchymal stem cell (MSC), which undergoes osteogenic differentiation in response to oscillatory fluid shear. Yet, the
Kohei Ueno et al.
The European journal of neuroscience, 28(10), 1956-1966 (2008-12-03)
In gustatory receptor neurons (GRNs) in Drosophila melanogaster, Gr5a and one of the Gr64s encode sugar receptors with seven transmembrane domains. Previously, we have shown that the responses to various sugars are depressed in DGsalpha mutant flies (Ueno et al.
Layla Al-Nakkash
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(1), 137-150 (2012-07-05)
Daily subcutaneous injections with the phytoestrogen genistein, 600 mg/ kg genistein/day (600G) significantly increased intestinal chloride (Cl(-)) secretion (I(sc), µA/cm(2)) in C57BL/6J female and male murine jejunum after 1-2-weeks treatment. In 600G females, basolateral application of the adenylate cyclase inhibitor
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M182-5MG | 04061832898902 |
| M182-25MG | 04061832898896 |
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