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Merck
CN

P0763

1,2-二棕榈酰-sn-甘油-3-磷酰胆碱

semisynthetic, ≥99%

别名:

PC, (7R)-4-羟基-N,N,N-三甲基-10-氧代-7-[(1-氧代十六烷基)氧基]- 3,5,9-三氧杂-4-磷杂二十五烷-1-铵4-氧化物， 内盐, 1,2-二十六酰- 锡 -甘油基-3-磷酸胆碱, 1,2-二棕榈酰-sn-甘油-3-磷酰胆碱, 1,2-二棕榈酰- L -卵磷脂, 1,2-双十六酰基-sn-甘油-3-磷酰胆碱, L-α-磷脂酰胆碱，二棕榈酰, L-β,γ-二棕榈酰-α-卵磷脂, PC(16:0/16:0), 二棕榈酰磷脂酰胆碱

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关于此项目

经验公式（希尔记法）:
C40H80NO8P
化学文摘社编号:
63-89-8
分子量:
734.04
NACRES:
NA.25
PubChem Substance ID:
24898128
UNSPSC Code:
12352211
EC Number:
200-567-6
MDL number:
MFCD00036903

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产品名称

1,2-二棕榈酰-sn-甘油-3-磷酰胆碱, semisynthetic, ≥99%

InChI key

KILNVBDSWZSGLL-KXQOOQHDSA-N

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

biological source

semisynthetic

assay

≥99%

form

powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

Quality Level

200

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相关类别

Application


  • η(6)-对伞花烃钌（II）配合物对模拟癌症和健康细胞膜的Langmuir单分子膜的影响与其毒性无关。：该研究探讨了η(6)-对伞花烃钌(II)复合物对模拟癌症和健康细胞膜的Langmuir单分子膜（包括1,2-二棕榈酰-sn-甘油-3-磷酸胆碱（DPPC））的影响，揭示了膜相互作用和细胞毒性机制（Wrobel et al., 2024）。

  • L-苯丙氨酸与混合脂膜中羰基的相互作用。：该研究探讨了L-苯丙氨酸与混合脂膜（含有 DPPC）中羰基的相互作用，以了解氨基酸在膜动力学和稳定性中的作用（Brandan et al., 2024）。

  • 存在脂质筏时布洛芬药物在模型膜中的空间排列。：该研究调查了以DPPC为成分时，布洛芬在含有脂质筏的模型膜中的空间排列，揭示了药物与膜的相互作用以及脂质筏在药物输送中的作用（Kashnik et al., 2024）。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000349438
0000349438
0000498306
0000498304
0000498293

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Johannes Thoma et al.
Chemical communications (Cambridge, England), 48(70), 8811-8813 (2012-07-28)
We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid
Edyta Paszko et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 202-210 (2012-11-20)
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan)
Fernando R Moya et al.
Pediatrics, 115(4), 1018-1029 (2005-04-05)
Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce
Julien Perino et al.
Antiviral research, 89(1), 89-97 (2010-11-26)
Vaccinia virus (VACV) was used as a surrogate of Variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection via the respiratory airway. Lung surfactant, a physiological barrier to infection encountered by the virus, is predominantly composed
John M Franck et al.
Journal of the American Chemical Society, 135(11), 4175-4178 (2013-01-26)
The translational hydration dynamics within 0.5-1.5 nm of the surface of a DPPC liposome, a model biomacromolecular surface, is analyzed by the recently developed Overhauser dynamic nuclear polarization (ODNP) technique. We find that dramatic changes to the bulk solvent cause
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