SML1933
TP-472N
≥98% (HPLC)
别名:
1-[8-[2-(Cyclopropylmethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-6-yl]-ethanone
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关于此项目
经验公式（希尔记法）:
C19H18N2O2
化学文摘社编号:
分子量:
306.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
TP-472N, ≥98% (HPLC)
InChI key
IDQWBZAMTQTECP-UHFFFAOYSA-N
SMILES string
O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Negative control probe for TP-472, a bromodomain BRD9/7 probe
TP-472N is a negative control probe for TP-472. TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. The BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC, is >30 fold selective for BRD9 over all other bromodomain family members except BRD7, and is suitable for in vivo applications. The negative control TP-472N is inactive against other bromodomains (>20μM against BRD9). For full characterization details of TP-472 and TP-472N, please visit the TP-472 probe summary on the Structural Genomics Consortium (SGC) website.
TP-472, the active BRD9/7 probe, is available from Sigma. To learn more about and purchase TP-472, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
TP-472, the active BRD9/7 probe, is available from Sigma. To learn more about and purchase TP-472, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits
TP-472N is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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