A3785
5-氨基乙酰丙酸盐 盐酸盐
≥98%, suitable for ligand binding assays
别名:
δ-氨基乙酰丙酸盐 盐酸盐, 5-氨基-4-氧代戊酸 盐酸盐, 5-氨基乙酰丙酸盐 盐酸盐, ALA
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关于此项目
线性分子式:
NH2CH2C(O)CH2CH2COOH · HCl
化学文摘社编号:
分子量:
167.59
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
226-679-5
MDL number:
Beilstein/REAXYS Number:
3690651
产品名称
5-氨基乙酰丙酸盐 盐酸盐, ≥98%
InChI key
ZLHFONARZHCSET-UHFFFAOYSA-N
InChI
1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
SMILES string
Cl[H].NCC(=O)CCC(O)=O
assay
≥98%
form
powder
technique(s)
ligand binding assay: suitable
mp
150 °C
storage temp.
−20°C
Quality Level
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Application
5-氨基乙酰丙酸盐酸盐可以用来激活或抑制HeLa和K562细胞系中血红素生物合成。它用于A431肿瘤携带小鼠光动力治疗。
Biochem/physiol Actions
5-氨基乙酰丙酸（5-ALA）是血红素生物合成的中间物，可以用于治疗癌症。它是一种非蛋白氨基酸。5-ALA同样用于农业。它可用作基于转移性淋巴结荧光诊断原卟啉 IX (PPIX)抑制剂。5-ALA可以用于疾病光动力诊疗，比如Paget疾病和HPV感染有关的宫颈尖锐湿疣。
血红素生物合成中间体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
农药列管产品
此项目有
ALA-PpIX variability quantitatively imaged in A431
epidermoid tumors using in vivo ultrasoundfluorescence
tomography and ex vivo assay
epidermoid tumors using in vivo ultrasoundfluorescence
tomography and ex vivo assay
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SPIE Proc., 8931 null
Treatment of HPV infection-associated cervical condylomata acuminata with 5-aminolevulinic acid-mediated photodynamic therapy.
Wang HW
Photochemistry and Photobiology, 88(3), 565-569 (2012)
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation
Deborah Chiabrando, et.al
The Journal of Clinical Investigation, 122(12), 4569-4579 (2012)
Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli
Junli Zhang
Scientific Reports, 5 (2015)
Francesca Bertino et al.
Pain, 160(12), 2766-2775 (2019-08-14)
Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous disorders of the peripheral nervous system mainly characterized by impaired nociception and autonomic dysfunction. We previously identified heme metabolism as a novel pathway contributing to sensory
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