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文件

A5626

氯化乙酰硫代胆碱

Name: 氯化乙酰硫代胆碱
Brand: SIGMA

≥99% (TLC), powder

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别名:

(2-Mercaptoethyl)trimethylammonium chloride acetate

线性分子式:

CH₃COSCH₂CH₂N(CH₃)₃Cl

CAS号:

6050-81-3

分子量:

197.73

EC 号:

227-953-7

MDL编号:

MFCD00038727

PubChem化学物质编号:

24278219

NACRES:

NA.83

质量水平

200

检测方案

≥99% (TLC)

形式

powder

溶解性

water: 100 mg/mL, clear to slightly hazy, colorless

储存温度

−20°C

SMILES string

[Cl-].CC(=O)SCC[N+](C)(C)C

InChI

1S/C7H16NOS.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChI key

GZYVLKKMMDFCKR-UHFFFAOYSA-M

Gene Information

human ... ACHE(43)

应用

氯化乙酰胆碱用于确定精液外泌体（SE）中乙酰胆碱酯酶的活性。也可用作乙酰胆碱酯酶的底物，对其动力学参数进行微量量热研究。

生化/生理作用

乙酰胆碱酯酶（AChE）酶在神经传递过程中起着重要的生理作用。

乙酰胆碱酯酶底物和烟碱型乙酰胆碱受体激动剂。

象形图

GHS05

警示用语：

Danger

危险声明

H318

预防措施声明

P280 - P305 + P351 + P338 + P310

危险分类

Eye Dam. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Specific inhibition of acetylcholinesterase as an approach to decrease muscarinic side effects during myasthenia gravis treatment.

Konstantin A Petrov et al.

Scientific reports, 8(1), 304-304 (2018-01-13)

Non-selective inhibitors of cholinesterases (ChEs) are clinically used for treatment of myasthenia gravis (MG). While being generally safe, they cause numerous adverse effects including induction of hyperactivity of urinary bladder and intestines affecting quality of patients life. In this study

Structural Isomerism and Enhanced Lipophilicity of Pyrithione Ligands of Organoruthenium(II) Complexes Increase Inhibition on AChE and BuChE.

Jerneja Kladnik et al.

International journal of molecular sciences, 21(16) (2020-08-13)

The increasing number of Alzheimer's disease (AD) cases requires the development of new improved drug candidates, possessing the ability of more efficient treatment as well as less unwanted side effects. Cholinesterase enzymes are highly associated with the development of AD

Synthetic analogs of stryphnusin isolated from the marine sponge Stryphnus fortis inhibit acetylcholinesterase with no effect on muscle function or neuromuscular transmission.

Lindon W K Moodie et al.

Organic & biomolecular chemistry, 14(47), 11220-11229 (2016-11-15)

The marine secondary metabolite stryphnusin (1) was isolated from the boreal sponge Stryphnus fortis, collected off the Norwegian coast. Given its resemblance to other natural acetylcholinesterase antagonists, it was evaluated against electric eel acetylcholinesterase and displayed inhibitory activity. A library

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Madison MN, et al.

Bio-protocol, 7(7) (2017)

Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: Role of ectonucleotidases and acetylcholinesterase activities.

Roberto M Maciel et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 559-568 (2016-10-04)

The present study investigated the protective effect of quercetin (Querc) on memory, anxiety-like behavior and impairment of ectonucleotidases and acetylcholinesterase (AChE) activities in brain of streptozotocin-induced diabetic rats (STZ-diabetes). The type 1 diabetes mellitus was induced by an intraperitoneal injection

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