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文件

A7009

Sigma-Aldrich

氨基胍 半硫酸盐

≥98%

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别名:
甲脒肼 半硫酸盐
线性分子式:
CH6N4 · 1/2H2SO4
CAS号:
996-19-0
分子量:
123.12
EC 号:
213-628-7
MDL编号:
MFCD00035665
PubChem化学物质编号:
24278013
NACRES:
NA.77

生物来源

synthetic (organic)

检测方案

≥98%

形式

powder

溶解性

water: 50 mg/mL, clear to very slightly hazy, colorless

储存温度

room temp

SMILES string

NNC(N)=N.NNC(N)=N.OS(O)(=O)=O

InChI

1S/2CH6N4.H2O4S/c2*2-1(3)5-4;1-5(2,3)4/h2*4H2,(H4,2,3,5);(H2,1,2,3,4)

InChI key

VKGQPUZNCZPZKI-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

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应用

氨基胍可抑制组成型和诱导型一氧化氮合成酶。氨基胍也被用于研究一氧化氮对排卵和卵巢类固醇生成和前列腺素产生的影响。

生化/生理作用

构成型和诱导型一氧化氮合酶两者都抑制

特点和优势

该化合物在受体分类和信号转导手册的一氧化氮合酶页面上有重点介绍。想要浏览手册的其他页面， 请单击此处。

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J Yamauchi et al.
Endocrinology, 138(9), 3630-3637 (1997-09-01)
Evidence supports the involvement of nitric oxide (NO) in ovarian physiology. The present study was undertaken to investigate the role of the NO/NO synthase (NOS) systems in ovulation, oocyte maturation, ovarian steroidogenesis, and PG production using in vitro perfused rabbit
Wei Chen et al.
Oxidative medicine and cellular longevity, 2022, 8854457-8854457 (2022-01-18)
Cerebral endothelial cells play an essential role in brain angiogenesis, and their function has been found to be impaired in diabetes. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite of glucose formed mainly during glycolysis, and its levels can be
Jong Jin Park et al.
Food chemistry, 338, 128150-128150 (2020-10-24)
This study aimed to develop efficient adsorption and desorption processes to purify phenolic compounds from Ecklonia cava. We compared the adsorption and desorption properties of five resins. HP2MG showed the highest adsorption and desorption capacities and adsorption rate; hence, it
Fernanda Hansen et al.
Amino acids, 48(2), 375-385 (2015-09-09)
Diabetes is a metabolic disease characterized by high fasting-glucose levels. Diabetic complications have been associated with hyperglycemia and high levels of reactive compounds, such as methylglyoxal (MG) and advanced glycation endproducts (AGEs) formation derived from glucose. Diabetic patients have a
Caroline Zanotto et al.
Molecular neurobiology, 56(5), 3538-3551 (2018-08-27)
Diabetes mellitus is a metabolic disorder that results in glucotoxicity and the formation of advanced glycated end products (AGEs), which mediate several systemic adverse effects, particularly in the brain tissue. Alterations in glutamatergic neurotransmission and cognitive impairment have been reported
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