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B0385

Beclomethasone

Name: Beclomethasone
Brand: SIGMA

≥99%, anti-inflammatory agent, powder

别名:

9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₉ClO₅

化学文摘社编号:

4419-39-0

分子量:

408.92

NACRES:

NA.77

PubChem Substance ID:

24278253

UNSPSC Code:

12352200

EC Number:

224-585-9

MDL number:

MFCD00135614

Assay:

≥99%

Form:

powder

Quality level:

100

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属性

产品名称

Beclomethasone, ≥99%

Quality Level

100

assay

≥99%

form

powder

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

InChI key

NBMKJKDGKREAPL-WOOYFSPWSA-N

Gene Information

human ... CYP1A2(1544)

说明

Application

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins. It has also been used to find the differential response of glucocorticoids in larval regeneration model.

Biochem/physiol Actions

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

A comparison of beclomethasone, salmeterol, and placebo in children with asthma

Simons, FER, et al.

The New England Journal of Medicine, 337(23), 1659-1665 (1997)

Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis.

Hong Ping Zhang et al.

Allergy and asthma proceedings, 35(4), 278-287 (2014-07-06)

It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not systematically assessed. This study was designed to systematically explore the evidence for montelukast, as

Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish.

Antonia Chatzopoulou et al.

Molecular and cellular endocrinology, 447, 61-70 (2017-03-01)

In humans, two splice variants of the glucocorticoid receptor (GR) exist: the canonical α-isoform, and the β-isoform, which has been shown to have a dominant-negative effect on hGRα. Previously, we have established the occurrence of a GR β-isoform in zebrafish

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全球贸易项目编号

货号	GTIN
B0385-100MG	04061832630984
B0385-1G	04061833419755
B0385-250MG	04061833419762