B8271
Bromoacetic acid N-hydroxysuccinimide ester
≥95%, powder
别名:
2,5-Dioxopyrrolidin-1-yl 2-bromoacetate, N-Hydroxysuccinimide bromoacetate
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关于此项目
经验公式（希尔记法）:
C6H6BrNO4
化学文摘社编号:
分子量:
236.02
NACRES:
NC.07
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
Bromoacetic acid N-hydroxysuccinimide ester, ≥95%, powder
InChI
1S/C6H6BrNO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
SMILES string
O=C(N1OC(CBr)=O)CCC1=O
InChI key
NKUZQMZWTZAPSN-UHFFFAOYSA-N
assay
≥95%
form
powder
reaction suitability
reagent type: cross-linking reagent
solubility
acetone: 25 mg/mL
DMF: soluble
functional group
NHS ester
shipped in
dry ice
storage temp.
−20°C
Quality Level
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Application
A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0.
Disclaimer
The bromoacetyl group is light sensitive.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
N Kolodny et al.
Analytical biochemistry, 187(1), 136-140 (1990-05-15)
A method described here for conjugating synthetic peptides to carrier proteins provides a convenient method for determining peptide-to-carrier protein ratios. N-Bromoacetyl-containing peptides are reacted in situ with carrier proteins in which the disulfide bonds were reduced with tri-n-butylphosphine. At pH
John S Mort et al.
Methods in molecular medicine, 100, 237-250 (2004-07-29)
The use of synthetic peptides to generate rabbit polyclonal anticatabolic neoepitope antibodies that can be used to study the presence of defined proteolytic cleavage sites in aggrecan is described. Principles of peptide design and methods for preparation and characterization of
M S Bernatowicz et al.
Analytical biochemistry, 155(1), 95-102 (1986-05-15)
Synthetic peptides derived from human fibrin were unidirectionally conjugated to three carrier proteins (bovine serum albumin, bovine alpha-lactalbumin, and keyhole limpet hemocyanin) by a method that employs N-succinimidyl bromoacetate. This heterobifunctional crosslinking reagent was prepared with a 79% yield in
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