B8279
Ro-20-1724
≥98% (HPLC), solid, cAMP phosphodiesterase inhibitor
别名:
Ro 20-1724
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关于此项目
经验公式（希尔记法）:
C15H22N2O3
CAS Number:
分子量:
278.35
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
Product Name
4-（3-丁氧基-4-甲氧基苄基）咪唑烷-2-酮, solid
生物来源
synthetic (organic)
质量水平
方案
≥98% (HPLC)
表单
solid
溶解性
ethanol: 7 mg/mL
H2O: insoluble
储存温度
room temp
SMILES字符串
CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
InChI
1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChI key
PDMUULPVBYQBBK-UHFFFAOYSA-N
基因信息
human ... LITAF(9516), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Pde4a(25638)
应用
4-(3-丁氧基-4-甲氧基苄基)咪唑烷-2-酮已用于：
- 作为环腺苷单磷酸(cAMP)磷酸二酯酶抑制剂来处理细胞，用于测定细胞内cAMP水平
- 作为无血清培养基成分
- 作为磷酸二酯酶抑制剂，研究蛋白酶激活受体-1 (PAR-1)激活对cAMP水平的影响
生化/生理作用
cAMP 磷酸二酯酶的抑制剂。在主动脉的血管平滑肌中的 IC50 值为 33 μM 。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Regulation of sleep by the short neuropeptide F (sNPF) in Drosophila melanogaster
Chen W, et al.
Insect Biochemistry and Molecular Biology, 43(9), 809-819 (2013)
Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose
Bodrato N, et al.
The Journal of biological chemistry, 284(22), 14777-14787 (2009)
Protease-activated receptor-1 stimulates Ca2+-dependent Cl- secretion in human intestinal epithelial cells
Buresi MC, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 281(2), G323-G332 (2001)
Nicoletta Bodrato et al.
The Journal of biological chemistry, 284(22), 14777-14787 (2009-03-31)
Abscisic acid (ABA) is a phytohormone regulating important functions in higher plants, notably responses to abiotic stress. Recently, chemical or physical stimulation of human granulocytes was shown to induce production and release of endogenous ABA, which activates specific cell functions.
Chien-Chung Chen et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(7), 1605-1617 (2010-03-20)
The mossy fiber synapses onto hippocampal CA3 neurons show unique molecular features and a wide dynamic range of plasticity. Although acute stress has been well recognized to alter bidirectional long-term synaptic plasticity in the hippocampal CA1 region and dentate gyrus
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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