B8279
Ro-20-1724
≥98% (HPLC), solid, cAMP phosphodiesterase inhibitor
别名:
Ro 20-1724
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关于此项目
经验公式（希尔记法）:
C15H22N2O3
化学文摘社编号:
分子量:
278.35
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
4-（3-丁氧基-4-甲氧基苄基）咪唑烷-2-酮, solid
SMILES string
CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
InChI
1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChI key
PDMUULPVBYQBBK-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
solid
solubility
ethanol: 7 mg/mL
H2O: insoluble
storage temp.
room temp
Quality Level
Gene Information
human ... LITAF(9516), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Pde4a(25638)
Application
4-(3-丁氧基-4-甲氧基苄基)咪唑烷-2-酮已用于：
- 作为环腺苷单磷酸(cAMP)磷酸二酯酶抑制剂来处理细胞，用于测定细胞内cAMP水平
- 作为无血清培养基成分
- 作为磷酸二酯酶抑制剂，研究蛋白酶激活受体-1 (PAR-1)激活对cAMP水平的影响
Biochem/physiol Actions
cAMP 磷酸二酯酶的抑制剂。在主动脉的血管平滑肌中的 IC50 值为 33 μM 。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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