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C127

CNQX

Name: CNQX
Brand: SIGMA

≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid

别名:

6-氰基-7-硝基喹喔啉-2,3-二酮, FG-9065

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关于此项目

经验公式（希尔记法）:

C₉H₄N₄O₄

化学文摘社编号:

115066-14-3

分子量:

232.15

UNSPSC Code:

12352200

PubChem Substance ID:

24892392

NACRES:

NA.77

MDL number:

MFCD00069232

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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属性

产品名称

CNQX, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL, H₂O: insoluble

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

Gene Information

rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)

说明

Application

CNQX已用于：

作为α-氨基-3-羟基-5-甲基-4-异噁唑丙酸(AMPA)/红藻氨酸阻断剂，研究其对胚胎多能干细胞(pESC)丝状伪足(cytoneme)形成的影响
作为谷氨酸阻断剂，降低触角叶中心神经元电流钳记录中的突触输入
作为非N-甲基-D-天冬氨酸(NMDA)受体阻断剂，研究其对大鼠心率的影响作用

Biochem/physiol Actions

有效的竞争性AMPA/红藻氨酸谷氨酸受体拮抗剂。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.

Haiyan Li et al.

Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)

Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that

Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.

Binbin Yan et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)

Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and

The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels.

Sutirtha Ray et al.

Pain, 160(4), 954-964 (2019-01-03)

Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless

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全球贸易项目编号

货号	GTIN
C127-50MG	04061833467251
C127-5MG	04061832089621
C127-25MG	04061833467244