C1493
Cilnidipine
≥98% (HPLC), powder
别名:
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester, FRC 8653
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关于此项目
经验公式（希尔记法）:
C27H28N2O7
化学文摘社编号:
分子量:
492.52
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
light yellow
溶解性
H2O: ≤2 mg/mL
DMSO: ≥20 mg/mL
SMILES字符串
COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC\C=C\c3ccccc3
InChI
1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
InChI key
KJEBULYHNRNJTE-DHZHZOJOSA-N
应用
Cilnidipine has been used:
- in cell viability assay of pheochromocytoma (nPC12) cells
- in photoirradiation and photodegradation studies
- to understand effect on albuminuria in diabetic nephropathy
生化/生理作用
A slow-acting Ca2+ channel blocker, antihypertensive; vasodilator.
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.
特点和优势
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
包装
Protect from high temperatures.
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Sayaka Masada et al.
Scientific reports, 9(1), 11852-11852 (2019-08-16)
In July 2018, certain valsartan-containing drugs were voluntary recalled in Japan owing to contamination with N-nitrosodimethylamine (NDMA), a probable human carcinogen. In this study, an HPLC method was developed for the quantitative detection of NDMA simultaneously eluted with valsartan. Good
Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway
Lee YJ, et al.
Journal of Neurochemistry, 111(1), 90-100 (2009)
Photoinduced Aromatization of Asymmetrically Substituted 1, 4-Dihydropyridine Derivative Drug Cilnidipine
Ahmad W
Journal of Photochemistry, 2014(1), 90-100 (2014)
Kazuomi Kario et al.
Journal of clinical hypertension (Greenwich, Conn.), 15(2), 133-142 (2013-01-24)
The Ambulatory Blood Pressure Control and Home Blood Pressure (Morning and Evening) Lowering By N-Channel Blocker Cilnidipine (ACHIEVE-ONE) trial is a large-scale clinical study on blood pressure (BP) and pulse rate (PR) in the real world with use of cilnidipine
Naresh Kumar et al.
Physiology & behavior, 105(5), 1148-1155 (2012-01-03)
The present study was designed to investigate the ameliorative role of cilnidipine and nimodipine in immobilization stress-induced behavioral alterations and memory defects in the mice. Acute stress was induced by immobilizing the mice for 150 min and stress-induced behavioral changes
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