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Merck
CN

C1493

Cilnidipine

≥98% (HPLC), powder

别名:

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester, FRC 8653

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关于此项目

经验公式（希尔记法）:
C27H28N2O7
化学文摘社编号:
132203-70-4
分子量:
492.52
NACRES:
NA.77
PubChem Substance ID:
24892414
UNSPSC Code:
12352200
MDL number:
MFCD00865853
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
protect from light

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产品名称

Cilnidipine, ≥98% (HPLC), powder

InChI key

KJEBULYHNRNJTE-DHZHZOJOSA-N

SMILES string

COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC\C=C\c3ccccc3

InChI

1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

light yellow

solubility

H2O: ≤2 mg/mL
DMSO: ≥20 mg/mL

Quality Level

100

相关类别

Application

Cilnidipine has been used:
  • in cell viability assay of pheochromocytoma (nPC12) cells
  • in photoirradiation and photodegradation studies
  • to understand effect on albuminuria in diabetic nephropathy

Biochem/physiol Actions

A slow-acting Ca2+ channel blocker, antihypertensive; vasodilator.
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Protect from high temperatures.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000521145
0000521147
0000521147
0000521145
0000518100

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Sayaka Masada et al.
Scientific reports, 9(1), 11852-11852 (2019-08-16)
In July 2018, certain valsartan-containing drugs were voluntary recalled in Japan owing to contamination with N-nitrosodimethylamine (NDMA), a probable human carcinogen. In this study, an HPLC method was developed for the quantitative detection of NDMA simultaneously eluted with valsartan. Good
Photoinduced Aromatization of Asymmetrically Substituted 1, 4-Dihydropyridine Derivative Drug Cilnidipine
Ahmad W
Journal of Photochemistry, 2014(1), 90-100 (2014)
Akira Takahara
Cardiovascular therapeutics, 27(2), 124-139 (2009-05-12)
Cilnidipine is a unique Ca(2+) channel blocker with an inhibitory action on the sympathetic N-type Ca(2+) channels, which is used for patients with hypertension in Japan. Cilnidipine has been clarified to exert antisympathetic actions in various examinations from cell to
Hiroaki Matsuoka et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 33(7), 455-462 (2011-06-09)
Recently, it has been demonstrated that L-/N-type calcium channel blockers (CCBs), cilnidipine, but not L-type CCB, decreased urinary protein in renin-angiotensin system (RAS), inhibitor-treated hypertensive patients with macroproteinuria. However, the antiproteinuric effect of cilnidipine was weaker in diabetic patients than
Combination Irbesartan/Amlodipine versus Irbesartan/Cilnidipine for Attenuation of Albuminuria in Rats with Streptozotocin-Induced Diabetic Nephropathy
Satoh M, et al.
Pharmaceutica Analytica Acta, 6(369), 2-2 (2015)
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