C2759
Carbonyl Cyanide m-Chlorophenylhydrazone
≥97% (TLC), powder, mitophagy inducer
别名:
m-Cl-CCP, CCCP, 羰基氰酯-3-氯苯基腙
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关于此项目
经验公式（希尔记法）:
C9H5ClN4
化学文摘社编号:
分子量:
204.62
Beilstein:
1842102
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
氰化羰基-3-氯苯腙, ≥97% (TLC), powder
质量水平
方案
≥97% (TLC)
表单
powder
颜色
yellow to orange
溶解性
DMSO: 100 mM
储存温度
−20°C
SMILES字符串
Clc1cccc(N\N=C(\C#N)C#N)c1
InChI
1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
InChI key
UGTJLJZQQFGTJD-UHFFFAOYSA-N
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应用
羰基氰化物间氯苯腙(CCCP)已用于：
- 抑制临床铜绿假单胞菌中的外排泵
- 抑制人Beas-2B支气管上皮细胞线粒体的氧化磷酸化活性
- 制备羰基氰化物间氯苯腙溶液，分析秀丽隐杆线虫的氧化和线粒体应激及线粒体诱导作用
生化/生理作用
羰基氰3-氯苯肼(CCCP)诱导哺乳动物细胞的有丝分裂吞噬。CCCP抑制少量电子传递链(ETC)蛋白的表达。线粒体中氧化磷酸化的质子载体(H+ 离子载体)和解耦体。表明对细胞钙有多种影响。抑制肝脂肪酶分泌，部分抑制pH梯度激活的刷状缘膜泡中Cl- 的摄取和Cl-/Cl- 交换活性。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
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