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安全信息

C5913

Sigma-Aldrich

4-氯汞苯甲酸

cysteine active site modifier

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别名:
4-氯苯甲酸汞, 对氯汞苯甲酸
线性分子式:
ClHgC6H4CO2H
CAS号:
59-85-8
分子量:
357.16
Beilstein:
3662892
EC 号:
200-442-6
MDL编号:
MFCD00002526
PubChem化学物质编号:
24278323
NACRES:
NA.77

描述

cysteine active site modifier

检测方案

≥98.5% (HPLC)

形式

powder

mp

287 °C (dec.) (lit.)

溶解性

1 M NaOH: 20 mg/mL, clear, colorless

SMILES string

OC(=O)c1ccc([Hg]Cl)cc1

InChI

1S/C7H5O2.ClH.Hg/c8-7(9)6-4-2-1-3-5-6;;/h2-5H,(H,8,9);1H;/q;;+1/p-1

InChI key

YFZOUMNUDGGHIW-UHFFFAOYSA-M

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应用

Can be used to inhibit some enzymes that require unmodified cysteine residues (e.g., adenylyl cyclase).

警示用语：

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

储存分类代码

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°C)

Not applicable

法规信息

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Vardan T Karamyan et al.
European journal of pharmacology, 590(1-3), 87-92 (2008-06-24)
In the present study the existence of a non-AT(1), non-AT(2) angiotensin (Ang) binding site unmasked by the organomercurial protease inhibitor p-chloromercuribenzoate (PCMB) was demonstrated in mouse brain membranes, consistent with observations previously reported in the rat (Karamyan and Speth, 2007b).
Gheorghe Benga et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 154(1), 105-109 (2009-05-26)
The water diffusional permeability (P(d)) of red blood cells (RBC) from agile wallaby (Macropus agilis), red-necked wallaby (Macropus rufogriseus) and Goodfellow's tree kangaroo (Dendrolagus goodfellowi) was monitored using an Mn(2+)-doping (1)H nuclear magnetic resonance (NMR) technique at 400 MHz. The
Gabriela Galicia-Vázquez et al.
Analytical biochemistry, 384(1), 180-188 (2008-10-18)
Protein-RNA interactions are involved in all facets of RNA biology. The identification of small molecules that selectively block such bimolecular interactions could provide insight into previously unexplored steps of gene regulation. Such is the case for regulation of eukaryotic protein
Sravanthi Cheeti et al.
International journal of pharmaceutics, 325(1-2), 48-54 (2006-08-05)
This study was aimed to identify the monocarboxylate transporters (MCTs) in HeLa cells and to delineate their role in transportation of L-lactic acid. The functional role of MCTs in lactic acid transport was evaluated at various mucosal pHs (4.5-7.4) or
Vardan T Karamyan et al.
Brain research, 1143, 83-91 (2007-02-20)
Efforts to protect radiolabeled angiotensins from metabolism during receptor binding assays date back more than 30 years. However, this continues to be a problem. This study focused on the effects of a protease inhibitor, p-chloromercuribenzoate (PCMB), on the binding of
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