D0633
7-(2,3-二羟丙基)茶碱
PDE inhibitor, powder
别名:
喘定
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关于此项目
经验公式（希尔记法）:
C10H14N4O4
化学文摘社编号:
分子量:
254.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
207-526-1
MDL number:
Beilstein/REAXYS Number:
284563
产品名称
7-(2,3-二羟丙基)茶碱,
InChI key
KSCFJBIXMNOVSH-UHFFFAOYSA-N
InChI
1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3
SMILES string
CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O
form
powder
mp
161-162 °C (lit.)
Quality Level
Gene Information
human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)
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Biochem/physiol Actions
7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Wei-Shan Huang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 795(2), 329-335 (2003-10-03)
A simple micellar electrokinetic chromatography is described for well resolution of theophylline, dyphylline and caffeine. The separation was performed at 25 degrees C using a background electrolyte consisting of 10mM borate buffer at pH 9 and 40 mM sodium dodecyl
Sinan Güres et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(1), 122-129 (2011-10-20)
The aim of this study was to use a mechanistically realistic mathematical model based on Fick's second law to quantitatively predict the release profiles from solid lipid extrudates consisting of a ternary matrix. Diprophylline was studied as a freely water-soluble
F Siepmann et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 216-222 (2009-09-10)
Kollidon SR-based matrix tablets containing various amounts of diprophylline were prepared and thoroughly characterized in vitro. This includes drug release measurements in 0.1M HCl and phosphate buffer pH 7.4, monitoring of changes in the tablet's height and diameter, morphology as
Mario Grassi et al.
International journal of pharmaceutics, 276(1-2), 107-114 (2004-04-29)
A mathematical model able to describe the release kinetics of two model drugs (Diprophylline and Theophylline) from partially coated hydroxypropylmethylcellulose (HPMC, Methocel) K4M) matrices is presented. As solvent interaction with the system and drug release can only take place in
Joshua Müller et al.
Journal of pharmaceutical and biomedical analysis, 53(4), 884-894 (2010-07-20)
A multivariate model was constructed by correlating Raman spectral data with coated amount of the API diprophylline using Partial Least Squares. In agreement with ICH guideline Q2 the method was validated in order to achieve the requirement of demonstrating that
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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