D5287
2′-脱氧肌苷
≥98%
别名:
9-(2-脱氧-β-D-呋喃核糖基)次黄嘌呤
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关于此项目
经验公式（希尔记法）:
C10H12N4O4
化学文摘社编号:
分子量:
252.23
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
212-964-1
Beilstein/REAXYS Number:
33517
MDL number:
Assay:
≥98%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
InChI key
VGONTNSXDCQUGY-RRKCRQDMSA-N
InChI
1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
biological source
synthetic (organic)
assay
≥98%
form
powder
impurities
inosine, essentially free
solubility
1 M NH4OH: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
2′-脱氧肌苷是次黄嘌呤的一种核苷形式。它是由活性氮引起的DNA损害的一种DNA损伤产物。2′-脱氧肌苷是通过N2O3由亚硝化脱氨而形成的。
2′-脱氧肌苷是一种由次黄嘌呤通过β-N9-糖苷键与2′-脱氧核糖连接而组成的核苷。DNA中的2′-脱氧肌苷可来自于腺苷的脱氨作用。2′-脱氧肌苷可作为模型化合物用于研究可能影响DNA结构的加合物形成和自由基化学。2′-脱氧肌苷可用于产生具有自我回避能力的杂交敏感型荧光DNA探针。
Application
2′-脱氧肌苷已被用于通过液相色谱串联质谱（LC-MS/MS）对单个DNA样品中的核苷形式DNA损伤进行定量。它也被用作高效液相色谱分析的标准品。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Bo Pang et al.
Carcinogenesis, 28(8), 1807-1813 (2007-03-10)
In an effort to define the prevalent DNA damage chemistry-associated chronic inflammation, we have quantified 12 DNA damage products in tissues from the SJL mouse model of nitric oxide (NO) overproduction. Using liquid chromatography-mass spectrometry/MS and immunoblot techniques, we analyzed
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Hybridization-sensitive fluorescent probes have an inherent disadvantage: self-dimerization of the probe prevents the fluorescence quenching prior to hybridization with the target, resulting in a high background signal. To avoid self-dimerization of probes, we focused on a base pair formed by
Chia-Chia Lee et al.
DNA repair, 9(10), 1073-1079 (2010-08-11)
Deoxyinosine (dI) in DNA can arise from hydrolytic or nitrosative deamination of deoxyadenosine. It is excised in a repair pathway that is initiated by endonuclease V, the nfi gene product, in Escherichia coli. Repair was studied in vitro using M13mp18
Susen Hartmann et al.
Clinical chemistry, 52(6), 1127-1137 (2006-04-15)
Clinical presentation and disease severity in disorders of purine and pyrimidine metabolism vary considerably. We present a method that allows comprehensive, sensitive, and specific diagnosis of the entire spectrum of abnormalities in purine and pyrimidine metabolism in 1 analytical run.
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