D5287
2′-脱氧肌苷
≥98%
别名:
9-(2-脱氧-β-D-呋喃核糖基)次黄嘌呤
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关于此项目
经验公式（希尔记法）:
C10H12N4O4
化学文摘社编号:
分子量:
252.23
Beilstein:
33517
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
生物来源
synthetic (organic)
质量水平
方案
≥98%
表单
powder
杂质
inosine, essentially free
溶解性
1 M NH4OH: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
InChI
1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
InChI key
VGONTNSXDCQUGY-RRKCRQDMSA-N
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应用
2′-脱氧肌苷已被用于通过液相色谱串联质谱（LC-MS/MS）对单个DNA样品中的核苷形式DNA损伤进行定量。它也被用作高效液相色谱分析的标准品。
生化/生理作用
2′-脱氧肌苷是一种由次黄嘌呤通过β-N9-糖苷键与2′-脱氧核糖连接而组成的核苷。DNA中的2′-脱氧肌苷可来自于腺苷的脱氨作用。2′-脱氧肌苷可作为模型化合物用于研究可能影响DNA结构的加合物形成和自由基化学。2′-脱氧肌苷可用于产生具有自我回避能力的杂交敏感型荧光DNA探针。
2′-脱氧肌苷是次黄嘌呤的一种核苷形式。它是由活性氮引起的DNA损害的一种DNA损伤产物。2′-脱氧肌苷是通过N2O3由亚硝化脱氨而形成的。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Nobuyuki Horinouchi et al.
Applied microbiology and biotechnology, 71(5), 615-621 (2005-11-12)
2'-Deoxyribonucleosides are important as building blocks for the synthesis of antisense drugs, antiviral nucleosides, and 2'-deoxyribonucleotides for polymerase chain reaction. The microbial production of 2'-deoxyribonucleosides from simple materials, glucose, acetaldehyde, and a nucleobase, through the reverse reactions of 2'-deoxyribonucleoside degradation
Kok Seong Lim et al.
Nature protocols, 1(4), 1995-2002 (2007-05-10)
Several studies examining DNA deamination have published levels of 2'-deoxyinosine that illustrated a large variation between studies. Most of them are the result of artifactual DNA deamination that occurs during the process of sample preparation, particularly acid hydrolysis. This protocol
Susen Hartmann et al.
Clinical chemistry, 52(6), 1127-1137 (2006-04-15)
Clinical presentation and disease severity in disorders of purine and pyrimidine metabolism vary considerably. We present a method that allows comprehensive, sensitive, and specific diagnosis of the entire spectrum of abnormalities in purine and pyrimidine metabolism in 1 analytical run.
Min Dong et al.
Chemical research in toxicology, 19(1), 50-57 (2006-01-18)
Nitric oxide (NO) is a physiologically important molecule that has been implicated in the pathophysiology of diseases associated with chronic inflammation, such as cancer. While the complicated chemistry of NO-mediated genotoxicity has been extensively study in vitro, neither the spectrum
Jing Zhang et al.
Chemical communications (Cambridge, England), 46(37), 6986-6988 (2010-08-24)
A novel electrochemical biosensor for the genotyping/detection of single-nucleotide polymorphisms (SNPs) of trace oral-cancer salivary DNA based on junction probes containing 2'-deoxyinosine (dI) residues is described.
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