Merck
CN

D6140

Sigma-Aldrich

地美环素 盐酸盐

powder or crystals

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别名:
7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride
经验公式(希尔记法):
C21H21ClN2O8 · HCl
CAS号:
分子量:
501.31
Beilstein:
3849198
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.75

检测方案

89.5-102.0% anhydrous basis

形式

powder or crystals

technique(s)

cell culture | mammalian: suitable

溶解性

soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES string

Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O

InChI

1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

InChI key

GVSJQNRGSCOSNJ-KBHRXELFSA-N

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一般描述

Chemical structure: tetracycline

生化/生理作用

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

分析证书(COA)

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示例

T1503
货号
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25G
包装规格/数量

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1000309185

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is the solubility of Product D6140, Demeclocycline hydrochloride? 

    Product D6140, Demeclocycline hydrochloride, has been found to be soluble in water at 20mg/ml, with heat as needed.  This will yield a clear yellow to very dark green-yellow solution.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Bone remodeling and regeneration are dependent on resident stem/progenitor cells with the ability to replenish mature osteoblasts and repair the skeleton. Using lineage tracing approaches, we identified a population of Dmp1+ cells that reside within cortical bone and are distinct
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Traditional culture-based techniques for assessing infection of the root canal system are difficult to use and prone to error. Real-time assessment of the microbial status of the root canal system using laser fluorescence would help address these limitations. This study
P Lenherr et al.
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