D6500
2′-脱氧腺苷-5′-三磷酸 二钠盐
≥97%
别名:
数据-Na 2
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关于此项目
经验公式（希尔记法）:
C10H14N5Na2O12P3
化学文摘社编号:
分子量:
535.15
EC 号:
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
生物来源
natural (inorganic)
质量水平
方案
≥97%
表单
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
[Na+].[Na+].Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O3
InChI
1S/C10H16N5O12P3.2Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;/q;2*+1/p-2/t5-,6+,7?;;/m0../s1
InChI key
JEKDCIBJADJZSK-LNUHRGGJSA-L
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相关类别
应用
2′-脱氧腺苷 5′-三磷酸二钠盐已用于：
- Smac-X-连锁凋亡蛋白抑制剂(Smac-XIAP)结合试验。
- 作为聚合酶链式反应 (PCR) 的组成部分，使用 AM-毒素引物。
- 测定与转录终止因子Rho的亲和常数 (Kd)。
- 测定多聚 ADP-核糖聚合酶1(PAPR-1)的活性。
2'-脱氧腺苷-5'-三磷酸 (dATP) 被多种聚合酶（包括 DNA 聚合酶和逆转录酶）用作底物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA
Gemble S, et al.
PLoS Genetics, 11(7), e1005384-e1005384 (2015)
Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64
Cheng J, et al.
American Journal of Human Genetics, 89(1), 56-66 (2011)
J E Reardon
Biochemistry, 31(18), 4473-4479 (1992-05-12)
Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templates. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was almost as efficient a substrate (kcat/Km) as dTTP for the enzyme. In contrast, the
Fadia Haddad et al.
Methods in molecular biology (Clifton, N.J.), 630, 261-270 (2010-03-20)
Reverse transcription (RT) is the synthesis of complementary deoxyribonucleic acids (DNA) from single-stranded ribonucleic acid (RNA) templates. This process is catalyzed by the reverse transcriptase enzyme, which is the replicating enzyme of retroviruses. Reverse transcriptase was discovered in 1970, and
Michael Trostler et al.
Biochemistry, 48(21), 4633-4641 (2009-04-08)
We used a series of dATP and dGTP analogues to determine how DNA polymerase I from Bacillus stearothermophilus (BF), a prototypical A family polymerase, uses N-1, N(2), N-3, and N(6) of purine dNTPs to differentiate between right and wrong nucleotide
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