D9175
硝苯呋海因 钠盐
Ca2+ release from sarcoplasmic reticulum inhibitor, solid
别名:
1-[[[5-(4-硝基苯)-2-呋喃基]亚甲基氨基]-2,4-咪唑啉二酮 钠盐
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关于此项目
经验公式（希尔记法）:
C14H9N4NaO5
化学文摘社编号:
分子量:
336.23
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
硝苯呋海因 钠盐,
Quality Level
SMILES string
[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O
InChI key
KSRLIXGNPXAZHD-HAZZGOGXSA-M
InChI
1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
form
solid
originator
JHP Pharmaceuticals
Gene Information
human ... RYR1(6261), RYR3(6263)
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Biochem/physiol Actions
肌浆网 Ca2+ 释放的抑制剂；肌肉松弛剂。
Features and Benefits
《受体分类和信号转导》手册的 InsP3/Ryanodine 受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由JHP Pharmaceuticals开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Beth A McNally et al.
Frontiers in physiology, 12, 737291-737291 (2021-10-16)
Daily regulation of Ca2+ - and voltage-activated BK K+ channel activity is required for action potential rhythmicity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the brain's circadian clock. In SCN neurons, BK activation is dependent upon multiple types of
G Haskó et al.
British journal of pharmacology, 124(6), 1099-1106 (1998-08-28)
1. Intracellular calcium has been suggested to be an important mediator of the cellular response in endotoxaemia and shock. Dantrolene is an agent that interferes with intracellular calcium fluxes resulting in a decreased availability of calcium in the cytoplasm. Here
S K Song et al.
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Severe bloodstream-borne infection--i.e., sepsis--and the resulting multiorgan failure are now the most common cause of death in many intensive care units. One of the most fundamentally important and controversial issues concerning the pathophysiology of sepsis is the role of intracellular
Douglas E Brenneman et al.
Journal of molecular neuroscience : MN, 66(1), 121-134 (2018-08-16)
Cannabidiol (CBD) exhibits neuroprotective properties in many experimental systems. However, development of CBD as a drug has been confounded by the following: (1) low potency; (2) a large number of molecular targets; (3) marginal pharmacokinetic properties; and (4) designation as
Jiao Liu et al.
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Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly
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