E7881
大黄素
from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor
别名:
1,3,8-三羟基-6-甲基-9,10-蒽醌, 1,3,8-三羟基-6-甲基蒽醌, 6-甲基-1,3,8-三羟基蒽醌, 大黃甘, 朱砂莲甲素, 泻素, 泻鼠李树皮, 虎杖大黄素
Product Name
大黄素, from Frangula bark, ≥90% (HPLC)
生物来源
Frangula bark
质量水平
方案
≥90% (HPLC)
溶解性
DMSO: soluble
aqueous base: soluble
ethanol: soluble
储存温度
2-8°C
SMILES字符串
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
基因信息
human ... CSNK2A1(1457), CSNK2B(1460), ELA2(1991), NFKB1(4790), NKAP(79576), NKRF(55922)
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一般描述
大黄素是一种从大黄 (Rheum palmatum) 中提取出来的蒽醌衍生物。 它具有抗菌、 抗肿瘤、抗炎和抗血管生成等作用。大黄素具有细胞毒性作用、诱导细胞凋亡并刺激缺氧诱导因子1α、谷胱甘肽 S-转移酶P和 N-乙酰转移酶的表达。 它可以抑制前列腺癌细胞的生长。 大黄素被用于治疗便秘和痔疮。它显示出免疫抑制和抗糖尿病作用。
应用
大黄素已被用于：
- 研究其对脂多糖 (LPS) 诱导的心肌炎炎症损伤的调控机制
- 作为开发和验证高效液相色谱 (HPLC)-光电二极管阵列 (PDA) 检测的参考标准品
- 抑制 Tau 聚集
- 用于直接结合检测
生化/生理作用
抑制 NF-κB 活化和粘附分子表达。酪蛋白激酶 2 (CK2) 抑制剂。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Anticancer potential of emodin
Hsu SC and Chung JG
BioMedicine, 2(3), 108-116 (2012)
Sheng-Zhang Lin et al.
PloS one, 7(8), e42146-e42146 (2012-08-10)
Emodin has been showed to induce apoptosis of pancreatic cancer cells and inhibit tumor growth in our previous studies. This study was designed to investigate whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism. In accordance
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