E8750
α-雌二醇
synthetic (organic), ≥98% (TLC), Endogenous estrogen receptor agonist, powder
别名:
1,3,5(10)雌甾三烯-3,17α-二醇, 3,17α-二羟基-1,3,5(10)-雌三烯, 雌二醇
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关于此项目
经验公式（希尔记法）:
C18H24O2
化学文摘社编号:
分子量:
272.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-354-8
MDL number:
产品名称
α-雌二醇, powder, ≥98% (TLC)
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
color
white to slight yellow
solubility
ethanol: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
InChI key
VOXZDWNPVJITMN-SFFUCWETSA-N
Gene Information
human ... ESR1(2099), ESR2(2100)
rat ... Ar(24208)
Biochem/physiol Actions
雌二醇（称为 α 雌二醇或 17 α 雌二醇）是组织培养中人乳腺癌细胞中的一种具有生物活性的雌激素。17-雌二醇及其选择性受体 ER-X 不属于经典激素/受体内分泌系统，而是属于在发育中和成人大脑中具有重要的自分泌/旁分泌功能的系统。17-雌二醇可能对更年期的激素替代策略以及治疗阿尔茨海默病和缺血性中风等神经退行性疾病具有重大意义。
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signalword
Danger
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Wolf Dietrich et al.
Fertility and sterility, 95(4), 1247-1255 (2010-12-07)
To clarify, whether uterine endothelial proliferation could be regulated via an autocrine estrogen producing mechanism or direct actions of testosterone. In vitro study. Tertiary care facility. Human myometrial tissue obtained from 40 women undergoing hysterectomy without further intrauterine pathology. Cell
Raphaël Bonnet et al.
Frontiers in oncology, 10, 557643-557643 (2020-11-27)
T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive subtype of leukemia for which important progress in treatment efficiency have been made in the past decades to reach a cure rate of 75%-80% nowadays. It is nevertheless mandatory to find new
Jennifer R Wardell et al.
Biology of reproduction, 89(5), 116-116 (2013-09-27)
Estrogen signaling in the ovary is a fundamental component of normal ovarian function, and evidence also indicates that excessive estrogen is a risk factor for ovarian cancer. We have previously demonstrated that the gonadally enriched TFIID subunit TAF4B, a paralog
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E8750-1G | 04061833608845 |
| E8750-100MG | 04061833608838 |
| E8750-500MG | 04061832850078 |