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E9750

雌素酮

Name: 雌素酮
Brand: SIGMA

≥99% (HPLC), powder, estrogen receptor agonist

别名:

3-羟基雌甾-1,3,5(10)-三烯-17-酮, 雌(三烯酚)酮, 雌酮

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About This Item

经验公式（希尔记法）:

C₁₈H₂₂O₂

CAS Number:

53-16-7

分子量:

270.37

Beilstein:

1915077

EC 号:

200-164-5

MDL编号:

MFCD00003620

UNSPSC代码:

51111800

PubChem化学物质编号:

24278427

NACRES:

NA.77

Product Name

雌素酮, ≥99%

生物来源

synthetic (organic)

质量水平

200

无菌性

non-sterile

方案

≥99%

表单

powder

mp

258-260 °C (lit.)

溶解性

dioxane: 50 mg/mL, clear, colorless to very faintly yellow

运输

ambient

储存温度

room temp

SMILES字符串

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

InChI

1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

InChI key

DNXHEGUUPJUMQT-CBZIJGRNSA-N

基因信息

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Esr1(24890)

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一般描述

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

应用

Estrone has been used:

as medium supplement for hormone based degranulation studies of natural killer cells
as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

生化/生理作用

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.