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E9750

雌素酮

Name: 雌素酮
Brand: SIGMA

≥99% (HPLC), powder, estrogen receptor agonist

别名:

3-羟基雌甾-1,3,5(10)-三烯-17-酮, 雌(三烯酚)酮, 雌酮

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₂O₂

化学文摘社编号:

53-16-7

分子量:

270.37

NACRES:

NA.77

PubChem Substance ID:

24278427

UNSPSC Code:

51111800

EC Number:

200-164-5

MDL number:

MFCD00003620

Beilstein/REAXYS Number:

1915077

Assay:

≥99%

Form:

powder

Quality level:

200

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属性

产品名称

雌素酮, ≥99%

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥99%

form

powder

mp

258-260 °C (lit.)

solubility

dioxane: 50 mg/mL, clear, colorless to very faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

InChI

1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

InChI key

DNXHEGUUPJUMQT-CBZIJGRNSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Esr1(24890)

说明

General description

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Application

Estrone has been used:

as medium supplement for hormone based degranulation studies of natural killer cells
as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Biochem/physiol Actions

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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商品

Discover Bioactive Small Molecules for ADME/Tox

Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids

Lopes-Coelho F, et al.

Molecular and cellular endocrinology, 462(9), 93-106 (2018)

Functional luteolysis in the rhesus monkey: ovarian estrogen and progesterone during the luteal phase of the menstrual cycle

Butler, WR and Knobil E.

Endocrinology, 96(6), 1509-1512 (1975)

Creation of a new portable biosensor for water toxicity determination

Eltzov E, et al.

Sensors and Actuators B, Chemical, 221(9), 1044-1054 (2015)

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全球贸易项目编号

货号	GTIN
E9750-500MG	04061833609187
E9750-1G	04061835556779
E9750-25G	04061833609170
E9750-5G	04061833609194