F7129
5-氟胞嘧啶
nucleoside analog
别名:
4-氨基-5-氟-2(1H)-嘧啶酮, 氟胞嘧啶
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关于此项目
经验公式（希尔记法）:
C4H4FN3O
化学文摘社编号:
分子量:
129.09
UNSPSC Code:
41116107
NACRES:
NA.32
PubChem Substance ID:
EC Number:
217-968-7
Beilstein/REAXYS Number:
127285
MDL number:
产品名称
5-氟胞嘧啶, nucleoside analog
InChI key
XRECTZIEBJDKEO-UHFFFAOYSA-N
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
SMILES string
NC1=NC(=O)NC=C1F
assay
≥99% (TLC)
Quality Level
form
powder
mol wt
129.09 g/mol
concentration
≤100% (Flucytosine)
color
white to off-white
mp
298-300 °C (dec.) (lit.)
solubility
formic acid: 50 mg/mL, colorless to faintly yellow
λmax
285-287 nm
fluorescence
(EmM Anhydrous 8.8 - 9.4, pH 1.0)
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes
protein synthesis | interferes
storage temp.
2-8°C
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Application
用于 TMP 生物合成研究。
Biochem/physiol Actions
具有抗真菌活性的核苷类似物。 5-FC由胞嘧啶脱氨基酶脱氨，可产生5-氟尿嘧啶，导致RNA密码错编。 5-氟尿嘧啶可抑制DNA和RNA的合成，干扰核糖体蛋白质合成。
General description
化学结构：核苷
A Gomez-Lopez et al.
Antimicrobial agents and chemotherapy, 52(4), 1506-1509 (2008-02-21)
We describe the prevalences and susceptibility profiles of two recently described species, Candida metapsilosis and Candida orthopsilosis, related to Candida parapsilosis in candidemia. The prevalences of these species (1.7% for C. metapsilosis and 1.4% for C. orthopsilosis) are significant. Differences
Francesco Imperi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7458-7463 (2013-04-10)
Although antibiotic resistance represents a public health emergency, the pipeline of new antibiotics is running dry. Repurposing of old drugs for new clinical applications is an attractive strategy for drug development. We used the bacterial pathogen Pseudomonas aeruginosa as a
Johanna K Kaufmann et al.
The Journal of investigative dermatology, 133(4), 1034-1042 (2012-12-12)
Effective treatment modalities for advanced melanoma are desperately needed. An innovative approach is virotherapy, in which viruses are engineered to infect cancer cells, resulting in tumor cell lysis and an amplification effect by viral replication and spread. Ideally, tumor selectivity
Hong Jun Lee et al.
Cancer letters, 335(1), 58-65 (2013-02-09)
Prostate cancer is the most common malignancy among men. Prostate cancer-related deaths are largely attributable to the development of hormone resistance in the tumor. No effective chemotherapy has yet been developed for advanced prostate cancer. It is desirable if a
C Wang et al.
Cancer gene therapy, 19(11), 796-801 (2012-09-29)
In our previous works, we demonstrated that human neural stem cells (NSCs) transduced with the cytosine deaminase (CD) gene showed remarkable 'bystander killer effect' on glioma and medulloblastoma cells after administration of the prodrug 5-fluorocytosine (5-FC). In addition, herpes simplex
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