F7129
5-氟胞嘧啶
nucleoside analog
别名:
4-氨基-5-氟-2(1H)-嘧啶酮, 氟胞嘧啶
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关于此项目
经验公式（希尔记法）:
C4H4FN3O
化学文摘社编号:
分子量:
129.09
UNSPSC Code:
41116107
NACRES:
NA.32
PubChem Substance ID:
EC Number:
217-968-7
Beilstein/REAXYS Number:
127285
MDL number:
Quality Level
assay
≥99% (TLC)
form
powder
mol wt
129.09 g/mol
concentration
≤100% (Flucytosine)
color
white to off-white
mp
298-300 °C (dec.) (lit.)
solubility
formic acid: 50 mg/mL, colorless to faintly yellow
λmax
285-287 nm
fluorescence
(EmM Anhydrous 8.8 - 9.4, pH 1.0)
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, protein synthesis | interferes
storage temp.
2-8°C
SMILES string
NC1=NC(=O)NC=C1F
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
InChI key
XRECTZIEBJDKEO-UHFFFAOYSA-N
General description
化学结构：核苷
Application
用于 TMP 生物合成研究。
Biochem/physiol Actions
具有抗真菌活性的核苷类似物。 5-FC由胞嘧啶脱氨基酶脱氨，可产生5-氟尿嘧啶，导致RNA密码错编。 5-氟尿嘧啶可抑制DNA和RNA的合成，干扰核糖体蛋白质合成。
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相关内容
Product Information Sheet
Annemarie E Brouwer et al.
Antimicrobial agents and chemotherapy, 51(3), 1038-1042 (2006-12-30)
In a randomized controlled trial of amphotericin B-based therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis in Thailand, we also compared the mycological efficacy, toxicity, and pharmacokinetics of oral versus intravenous flucytosine at 100 mg/kg of body weight/day for the
Francesco Imperi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7458-7463 (2013-04-10)
Although antibiotic resistance represents a public health emergency, the pipeline of new antibiotics is running dry. Repurposing of old drugs for new clinical applications is an attractive strategy for drug development. We used the bacterial pathogen Pseudomonas aeruginosa as a
P Francis et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 15(6), 1003-1018 (1992-12-01)
Flucytosine is an antifungal agent useful in combination with amphotericin B in the treatment of several deeply invasive mycoses. The potentially dose-limiting, hematologic, gastrointestinal, and hepatic toxicities of flucytosine lead to a reluctance to use it in myelosuppressed patients. To
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F7129-5G | 04061833619285 |
| F7129-1G | 04061835506316 |