F8257
氟桂嗪 二盐酸盐
≥98% (TLC), T-type Ca2+/Na+ channel blocker
别名:
1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C26H26F2N2 · 2HCl
化学文摘社编号:
分子量:
477.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-216-6
MDL number:
Beilstein/REAXYS Number:
4284243
Assay:
≥98% (TLC)
Quality level:
产品名称
氟桂嗪 二盐酸盐, ≥98% (TLC)
InChI key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
InChI
1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
SMILES string
Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
assay
≥98% (TLC)
originator
Johnson & Johnson
storage temp.
2-8°C
Quality Level
正在寻找类似产品? 访问 产品对比指南
General description
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Application
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Biochem/physiol Actions
阻断 T 型 Ca2+/Na+ 通道。
阻断 T 型 Ca2+/Na+ 通道；抑制嗜铬细胞中由 K+ 诱导的儿茶酚胺释放。
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy
Overweg J, et al.
Epilepsia, 25(2), 217-222 (1984)
Effects of flunarizine on induced calcium transients as measured in fura-2-loaded neurons of the rat dorsal root ganglion
Leybaert L, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 348(3), 269-274 (1993)
The effect of flunarizine on penicillin model epilepsy in rats
BAGIRICI F, et al.
Journal of Experimental and Clinical Medicine, 16(4) (1999)
Flunarizine
Holmes B, et al.
Drugs, 27(1), 6-44 (1984)
Lin-Peng Wang et al.
Pain, 152(8), 1864-1871 (2011-05-28)
Insufficient clinical trial data were available to prove the efficacy of acupuncture for migraine prophylaxis. A multicenter, double-dummy, single-blinded, randomized controlled clinical trial was conducted at the outpatient departments of acupuncture at 5 hospitals in China to evaluate the effectiveness
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持