F8257
氟桂嗪 二盐酸盐
≥98% (TLC), T-type Ca2+/Na+ channel blocker
别名:
1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C26H26F2N2 · 2HCl
化学文摘社编号:
分子量:
477.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-216-6
MDL number:
Beilstein/REAXYS Number:
4284243
产品名称
氟桂嗪 二盐酸盐, ≥98% (TLC)
InChI key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
InChI
1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
SMILES string
Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
assay
≥98% (TLC)
originator
Johnson & Johnson
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
阻断 T 型 Ca2+/Na+ 通道。
阻断 T 型 Ca2+/Na+ 通道；抑制嗜铬细胞中由 K+ 诱导的儿茶酚胺释放。
Application
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Effects of flunarizine on induced calcium transients as measured in fura-2-loaded neurons of the rat dorsal root ganglion
Leybaert L, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 348(3), 269-274 (1993)
Flunarizine
Holmes B, et al.
Drugs, 27(1), 6-44 (1984)
Barbara Budzynska et al.
Behavioural brain research, 228(1), 144-150 (2011-12-20)
The motivational component of drug withdrawal may contribute to drug seeking and relapse through the negative reinforcement-related process; thus, it is important to understand the mechanisms that mediate affective withdrawal behaviors. The present study was undertaken to examine the calcium-dependent
A Van Driessche et al.
Acta clinica Belgica, 67(2), 123-126 (2012-06-21)
Cyclic vomiting syndrome (CVS) is a functional disorder that is considered to be a manifestation of migraine diathesis. It is characterized by stereotypical episodes of severe nausea and vomiting lasting several hours or days, with return to baseline health between
Carlijn El Hoekstra et al.
The Cochrane database of systematic reviews, (7)(7), CD007960-CD007960 (2011-07-08)
Tinnitus is the perception of sound or noise in the absence of an external or internal acoustic stimulation. It is a common and potentially distressing symptom for which no adequate therapy exists. To assess the effectiveness of anticonvulsants in patients
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