F9427
盐酸非索非那定 盐酸盐
>98% (HPLC), H1 histamine receptor antagonist, powder
别名:
MDL 16455 盐酸盐, 羧酸非索芬那定 盐酸盐, 非索芬那定 盐酸盐
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关于此项目
经验公式（希尔记法）:
C32H39NO4 · HCl
化学文摘社编号:
分子量:
538.12
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
盐酸非索非那定 盐酸盐, >98% (HPLC)
SMILES string
Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4
InChI key
RRJFVPUCXDGFJB-UHFFFAOYSA-N
InChI
1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H
assay
>98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: soluble ≥5 mg/mL
originator
Sanofi Aventis
storage temp.
−20°C
Quality Level
Gene Information
human ... HRH1(3269)
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相关类别
Application
盐酸非索非那定在NCI-H661细胞中用作非阳离子两亲性抗组胺剂在小鼠中用作组胺H1受体拮抗剂
Biochem/physiol Actions
非索非那定是一种非镇静性 H1 组胺受体拮抗剂。
非索非那定用于治疗过敏性鼻炎、慢性特发性荨麻疹等。它可以缓解烦躁症状，属于第二代抗组胺。与其他抗组胺药相比，非索非那定能更好地缓解鼻塞症状。它是特非那定的活性代谢产物，能够降低过敏原引起的症状。
Features and Benefits
该化合物是 ADME Tox research 的特色产品。 单击此处 可发现更多功能的 ADME Tox 产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。
该化合物由Sanofi Aventis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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