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Merck
CN

F9428

丙酸氟替卡松

≥98% (HPLC), anti-inflammatory agent, powder

别名:

(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester

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关于此项目

经验公式（希尔记法）:
C25H31F3O5S
化学文摘社编号:
80474-14-2
分子量:
500.57
MDL编号:
MFCD00866007
UNSPSC代码:
12352200
PubChem化学物质编号:
329799785
NACRES:
NA.77

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产品名称

丙酸氟替卡松, ≥98% (HPLC), powder

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white

溶解性

DMSO: ≥10 mg/mL

创始人

GlaxoSmithKline

SMILES字符串

CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF

InChI

1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

InChI key

WMWTYOKRWGGJOA-CENSZEJFSA-N

基因信息

human ... NR3C1(2908)

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相关类别

一般描述

Fluticasone blocks mast cells, eosinophils, lymphocytes, neutrophils and macrophages.

生化/生理作用

Fluticasone propionate is a second generation glucocorticoid. Used as an anti-inflammatory agent for asthma. Shown to enhance eosinophil apoptosis in a concentration-dependent manner via the glucocorticoid receptor.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361f,H373

危险分类

Repr. 2 - STOT RE 2

靶器官

Endocrine system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000217417
0000217417
0000207384
0000207384
0000134002

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Small Animal Clinical Pharmacology (2008)
Fouad J Moawad et al.
The American journal of gastroenterology, 108(3), 366-372 (2013-02-13)
Patients with clinical symptoms of esophageal dysfunction and dense eosinophilic infiltration of the esophageal mucosa are suspected to have eosinophilic esophagitis (EoE). Topical steroids are often used as first-line therapy for EoE, although some patients respond clinically to proton pump
Marc Gauthier et al.
JCI insight, 2(13) (2017-07-07)
We previously showed that Th1/type 1 inflammation marked by increased IFN-γ levels in the airways can be appreciated in 50% of patients with severe asthma, despite high dose corticosteroid (CS) treatment. We hypothesized that a downstream target of IFN-γ, CXCL10
Melanie Manetsch et al.
PloS one, 8(3), e59635-e59635 (2013-03-28)
Mitogen-activated protein kinase phosphatase 1 (MKP-1) represses MAPK-driven signalling and plays an important anti-inflammatory role in asthma and airway remodelling. Although MKP-1 is corticosteroid-responsive and increased by cAMP-mediated signalling, the upregulation of this critical anti-inflammatory protein by long-acting β2-agonists and
David Price et al.
The Journal of allergy and clinical immunology, 131(3), 763-771 (2013-02-06)
Many asthmatic patients are unable to quit cigarettes; therefore information is needed on treatment options for smokers. This study evaluates 10 mg/d montelukast and 250 μg of fluticasone propionate twice daily, each compared with placebo, in patients with self-reported active smoking
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