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Merck
CN

H2270

氢化可的松琥珀酸酯 钠盐

powder, BioReagent, suitable for cell culture

别名:

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 钠盐, 氢化可的松 21-半琥珀酸酯 钠盐

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关于此项目

经验公式(希尔记法):
C25H33NaO8
化学文摘社编号:
分子量:
484.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
204-725-5
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥90% (HPLC)
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产品名称

氢化可的松琥珀酸酯 钠盐, powder, BioReagent, suitable for cell culture

InChI key

HHZQLQREDATOBM-CODXZCKSSA-M

InChI

1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

SMILES string

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]

biological source

synthetic (organic)

product line

BioReagent

assay

≥90% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

Gene Information

human ... NR3C1(2908)

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General description

用于上皮和内皮贴壁细胞培养的氢化可的松。

Application

Hydrocortisone 21-hemisuccinate sodium salt has been used as a supplement in Dulbecco′s modified Eagle medium/nutrient mixture F-12 (DMEM F12) for culturing oral squamous cell carcinoma (OSCC) cell lines and immortalized cone photoreceptor cell line.

pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

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Lot/Batch Number

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Manashi Priyadarshini et al.
Life sciences, 287, 120141-120141 (2021-11-15)
SARI (suppressor of activator protein (AP)-1, regulated by interferon (IFN) was identified as a novel tumor suppressor by applying subtraction hybridization to terminally differentiating human melanoma cells. The anti-tumor activity of SARI and the correlation between expression and cancer aggression
Ying Yuan et al.
Clinical epigenetics, 12(1), 135-135 (2020-09-08)
Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, displaying succinyltransferase activity, is recruited onto cccDNA to modulate HBV transcription in
Eleonora Nucera et al.
European journal of endocrinology, 164(1), 139-140 (2010-10-22)
We present the case of a woman with 'empty sella syndrome' who experienced generalized urticaria after the administration of sodium succinate hydrocortisone in two episodes. The patient underwent an allergological evaluation (prick, intradermal, and patch tests) with hydrocortisone sodium succinate
Naked & unconscious: crew's misdiagnosis could have cost patient her life.
Kimberly Doran
JEMS : a journal of emergency medical services, 37(10), 28-28 (2013-01-25)
Takahiro Michiba et al.
Auris, nasus, larynx, 40(2), 162-166 (2012-07-31)
Some patients with sudden sensorineural hearing loss (SSNHL) are frustrated by residual tinnitus even after accomplishment of the treatment for SSNHL. In the present prospective study, we examined patients' backgrounds of sex, laterality and age together with changes in hearing

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