H2270
氢化可的松琥珀酸酯 钠盐
powder, BioReagent, suitable for cell culture
别名:
11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 钠盐, 氢化可的松 21-半琥珀酸酯 钠盐
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关于此项目
经验公式（希尔记法）:
C25H33NaO8
化学文摘社编号:
分子量:
484.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
204-725-5
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥90% (HPLC)
InChI key
HHZQLQREDATOBM-CODXZCKSSA-M
InChI
1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
SMILES string
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]
biological source
synthetic (organic)
product line
BioReagent
assay
≥90% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... NR3C1(2908)
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General description
用于上皮和内皮贴壁细胞培养的氢化可的松。
Application
Hydrocortisone 21-hemisuccinate sodium salt has been used as a supplement in Dulbecco′s modified Eagle medium/nutrient mixture F-12 (DMEM F12) for culturing oral squamous cell carcinoma (OSCC) cell lines and immortalized cone photoreceptor cell line.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Manashi Priyadarshini et al.
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SARI (suppressor of activator protein (AP)-1, regulated by interferon (IFN) was identified as a novel tumor suppressor by applying subtraction hybridization to terminally differentiating human melanoma cells. The anti-tumor activity of SARI and the correlation between expression and cancer aggression
Daniel P Collins et al.
Hepatic medicine : evidence and research, 13, 37-44 (2021-04-23)
The SARS-CoV-2 virus may have direct or indirect effects on other human organs beyond the respiratory system and including the liver, via binding of the spike protein. This study investigated the potential direct interactions with the liver by comparing the
Ying Yuan et al.
Clinical epigenetics, 12(1), 135-135 (2020-09-08)
Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, displaying succinyltransferase activity, is recruited onto cccDNA to modulate HBV transcription in
Eleonora Nucera et al.
European journal of endocrinology, 164(1), 139-140 (2010-10-22)
We present the case of a woman with 'empty sella syndrome' who experienced generalized urticaria after the administration of sodium succinate hydrocortisone in two episodes. The patient underwent an allergological evaluation (prick, intradermal, and patch tests) with hydrocortisone sodium succinate
He Li et al.
Neurological research, 33(3), 295-299 (2011-04-26)
The effects of hydrocortisone sodium succinate on voltage-gated sodium current (I(Na)) were investigated by using the patch-clamp technique in trigeminal ganglion (TG) neurons of rat. I(Na) was recorded by whole-cell patch-clamp techniques after different concentrations of hydrocortisone sodium succinate were
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