产品名称
猪去氧胆酸, ≥98%
方案
≥98%
mp
200-201 °C (lit.)
SMILES字符串
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChI key
DGABKXLVXPYZII-SIBKNCMHSA-N
基因信息
human ... NR1H2(7376), NR1H3(10062)
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相关类别
一般描述
异去氧胆酸是天然存在的次级胆汁酸。它通过小肠中的肠道菌群产生。在大鼠中，异去氧胆酸在胆汁的肠肝循环过程中由鹅去氧胆酸获得。
应用
异去氧胆酸已被用于：
- 作为液相色谱-质谱（LC-MS）联用法分析大鼠细胞中血清胆汁酸的标准品。
- 作为生长培养基的成分用于研究其作为抗衰老小分子对pex5Δ (Δ) 菌株时序寿命 (CLS) 的影响。
- 作为分析小鼠细胞中胆汁酸组成和总胆汁酸的成分。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
C Cohen-Solal et al.
Biochimica et biophysica acta, 1257(2), 189-197 (1995-07-13)
The effects of hyodeoxycholic (HDCA) and alpha-hyocholic acids (alpha-HCA), on cholesterol, bile acid and lipoprotein metabolism, were studied in hamsters. The animals were fed a low cholesterol control diet supplemented with 0.1% HDCA or alpha-HCA for 3 weeks. In both
H Wietholtz et al.
Journal of hepatology, 24(6), 713-718 (1996-06-01)
Rifampin was shown to relieve pruritus in cholestatic liver diseases. There has been much speculation about the origin of pruritus, but it has not yet been comprehensively explained. The role of bile acids in producing pruritus is obscure and still
On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154.
K Einarsson
The Journal of biological chemistry, 241(3), 534-539 (1966-02-10)
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition
Cepa S, et al.
Toxicology and Applied Pharmacology, 338(9), 204-213 (2018)
Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice
Pierre J F, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 311(2), G286-G304 (2016)
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