H3878
猪去氧胆酸
≥98%, Bile acid
别名:
3α,6α-二羟基-5β-胆烷酸
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关于此项目
经验公式（希尔记法）:
C24H40O4
化学文摘社编号:
分子量:
392.57
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
201-483-2
MDL number:
Assay:
≥98%
Quality level:
产品名称
猪去氧胆酸, ≥98%
InChI
1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChI key
DGABKXLVXPYZII-SIBKNCMHSA-N
SMILES string
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
assay
≥98%
mp
200-201 °C (lit.)
Quality Level
Gene Information
human ... NR1H2(7376), NR1H3(10062)
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相关类别
General description
异去氧胆酸是天然存在的次级胆汁酸。它通过小肠中的肠道菌群产生。在大鼠中，异去氧胆酸在胆汁的肠肝循环过程中由鹅去氧胆酸获得。
Application
异去氧胆酸已被用于：
- 作为液相色谱-质谱（LC-MS）联用法分析大鼠细胞中血清胆汁酸的标准品。
- 作为生长培养基的成分用于研究其作为抗衰老小分子对pex5Δ (Δ) 菌株时序寿命 (CLS) 的影响。
- 作为分析小鼠细胞中胆汁酸组成和总胆汁酸的成分。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Karolina E Zaborska et al.
PloS one, 13(7), e0200908-e0200908 (2018-07-31)
Bile acids are critical contributors to the regulation of whole body glucose homeostasis; however, the mechanisms remain incompletely defined. While the hydrophilic bile acid subtype, ursodeoxycholic acid, has been shown to attenuate hepatic endoplasmic reticulum (ER) stress and thereby improve
Hang Zeng et al.
British journal of pharmacology, 174(8), 672-688 (2017-01-28)
Currently, ursodeoxycholic acid and obeticholic acid are the only two FDA-approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches need to be developed. Here we have evaluated the anti-cholestasis effects of Schisandrol B (SolB), a bioactive compound isolated from
On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154.
K Einarsson
The Journal of biological chemistry, 241(3), 534-539 (1966-02-10)
H Wietholtz et al.
Journal of hepatology, 24(6), 713-718 (1996-06-01)
Rifampin was shown to relieve pruritus in cholestatic liver diseases. There has been much speculation about the origin of pruritus, but it has not yet been comprehensively explained. The role of bile acids in producing pruritus is obscure and still
C Cohen-Solal et al.
Biochimica et biophysica acta, 1257(2), 189-197 (1995-07-13)
The effects of hyodeoxycholic (HDCA) and alpha-hyocholic acids (alpha-HCA), on cholesterol, bile acid and lipoprotein metabolism, were studied in hamsters. The animals were fed a low cholesterol control diet supplemented with 0.1% HDCA or alpha-HCA for 3 weeks. In both
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