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Merck
CN

H4126

醋酸氢化可的松

≥98% (HPLC), corticosteroid, powder

别名:

11β,17α,21-三羟基-4-孕烯-3,20-二酮 21-乙酸酯, 17-α-羟基皮质甾酮乙酸酯, 17-羟基皮质甾酮 21-乙酸酯, 21-乙酰氧基-4-孕烯-11β,17α-二醇-3,20-二酮, 4-孕烯-11β,17α,21-三醇-3,20-二酮 21-乙酸酯

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关于此项目

经验公式（希尔记法）:
C23H32O6
化学文摘社编号:
50-03-3
分子量:
404.50
NACRES:
NA.77
PubChem Substance ID:
24895620
UNSPSC Code:
12352200
EC Number:
200-004-4
MDL number:
MFCD00037714
Beilstein/REAXYS Number:
2066841
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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产品名称

醋酸氢化可的松, ≥98% (HPLC)

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

technique(s)

permeability assay: suitable

mp

223 °C (dec.) (lit.)

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... NR3C1(2908), SERPINA6(866)

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相关类别

General description

Hydrocortisone 21-acetate is an adrenocortical steroid. Hydrocortisone acts as an immunosuppressive drug and might suppress systemic inflammatory responses. It is used to treat rheumatoid arthritis and adrenal insufficiency. It also functions as an antiallergic agent.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1B - STOT RE 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCH5605
MKCJ6200
MKBW7364V
MKBT0288V
025K1123

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Principles of Orthomolecularism, 20-26 (2004)
Adrenal insufficiency in patients with cirrhosis and septic shock: effect of treatment with hydrocortisone on survival
Fernandez J, et al.
Hepatology, 44(5), 1288-1295 (2006)
Hydrocortisone and cortisone injected into arthritic joints: comparative effects of and use of hydrocortisone as a local antiarthritic agent
Hollander JL, et al.
Journal of the American Medical Association, 147(17), 1629-1635 (1951)
The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies, 20-26 (2014)
Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production
Attur MG, et al.
Inflammation Research, 49(1), 20-26 (2000)
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