Merck
CN
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文件

安全信息

I8283

Sigma-Aldrich

ICI 63,197

≥98% (HPLC)

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别名:
2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
经验公式（希尔记法）:
C9H13N5O
CAS号:
27277-00-5
分子量:
207.23
EC 号:
248-383-5
MDL编号:
MFCD06407961
PubChem化学物质编号:
24896137
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white

mp

161.8-163 °C

溶解性

DMSO: 13 mg/mL

储存温度

2-8°C

SMILES string

CCCN1C(=O)C(C)=Cn2nc(N)nc12

InChI

1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)

InChI key

UQDVRVNMIJAGRK-UHFFFAOYSA-N

生化/生理作用

Phosphodiesterase IV (PDE 4) inhibitor

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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H Wachtel et al.
Neuropharmacology, 25(10), 1119-1126 (1986-10-01)
The antidepressant potential of rolipram and inhibitors of phosphodiesterase (PDE) which are selective for cyclic AMP has previously been ascribed to enhancement of central noradrenergic transmission by the combination of two mechanisms of action: increase of synthesis of noradrenaline and
Z Merican et al.
Clinical and experimental pharmacology & physiology, 10(1), 35-44 (1983-01-01)
1. Cyclic AMP and cyclic GMP levels were determined in bovine splenic nerve segments in the absence and presence of (+/-)-isoprenaline, (-)-phenylephrine, clonidine and ICI 63 197 (a phosphodiesterase inhibitor). The chosen concentrations of adrenoceptor agonists were those which are
M R Mustafa et al.
European journal of pharmacology, 148(2), 171-177 (1988-03-29)
The effects of single and chronic doses of rolipram on the sensitivity of alpha 2-adrenoceptors have been compared with the phosphodiesterase inhibitors, isobutylmethylxanthine (IBMX) and ICI 63,197, and the antidepressant, desipramine. While pretreatment with a single dose of rolipram, ICI
J Abrahamsen et al.
Pharmacology & toxicology, 76(3), 185-189 (1995-03-01)
The possible involvement of cyclic AMP in the stimulation-evoked 3H-overflow from rabbit isolated ear artery preloaded with 3H-noradrenaline was studied. Cyclic AMP (10(-5)-3 x 10(-4)M), 8-bromo-cyclic AMP (3 x 10(-4)M) and adenosine (10(-5)-3 x 10(-4)M) enhanced stimulation-evoked 3H-overflow. Dibutyryl-cyclic AMP
M D Houslay
Cellular signalling, 2(1), 85-98 (1990-01-01)
Using experimentally derived data for the activities and kinetic constants of hepatocyte cyclic AMP phosphodiesterase isoenzymes together with the derived changes in adenylate cyclase activity, due to stimulation and subsequent desensitization by glucagon, a computer model was established to simulate
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