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安全信息

M3781

Sigma-Aldrich

6α-Methylprednisolone 21-hemisuccinate sodium salt

lyophilized powder

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别名:
6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate
线性分子式:
C26H33O8Na
CAS号:
2375-03-3
分子量:
496.53
EC 号:
219-156-8
MDL编号:
MFCD00152612
PubChem化学物质编号:
24896873
NACRES:
NA.77

生物来源

synthetic

无菌性

non-sterile

检测方案

≥98.00% (TLC)

形式

lyophilized powder

technique(s)

toxicology assay: suitable

溶解性

water: 50 mg/mL, clear, colorless to faintly yellow

运输

ambient

储存温度

room temp

SMILES string

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

Gene Information

human ... NR3C1(2908)

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应用

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

生化/生理作用

Glucocorticoid with slightly longer half-life than that of prednisolone.

外形

Lyophilized containing ~5% phosphate buffer salts.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H351 - H360

预防措施声明

P201 - P308 + P313

危险分类

Carc. 2 - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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Julio Urrutia et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 16(4), 439-442 (2011-04-30)
The effect of corticosteroids on spinal fusion healing has not yet been determined. To evaluate the effect of corticosteroids on lumbar spinal fusion we designed a randomized, placebo-controlled animal study using high-dose methylprednisolone sodium succinate, which is widely used in
Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy.
Sabrina Fourcade et al.
Archives of dermatology, 147(10), 1227-1228 (2011-10-19)
Takaaki Kitakawa et al.
Documenta ophthalmologica. Advances in ophthalmology, 124(3), 249-254 (2012-03-10)
The purpose of this study was to report a patient with acute zonal occult outer retinopathy (AZOOR) unilaterally, who received steroid pulse therapy. A 42-year-old woman presented with photopsias and severe vision loss in her left eye. Visual acuity was
Acute liver failure and aplastic anemia in an 11-year-old girl.
Ann Ming Yeh et al.
Digestive diseases and sciences, 56(8), 2237-2240 (2011-03-29)
Matthias D'Hondt et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 69(3), 232-240 (2012-01-21)
The short-term stability of extemporaneously prepared triple intrathecal therapy, containing cytarabine, methotrexate sodium, and methylprednisolone sodium succinate, was evaluated. Three batches of triple intrathecal solution were prepared using commercially available products and stored in three different packaging materials (plastic syringe
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