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Merck
CN

M3781

6α-Methylprednisolone 21-hemisuccinate sodium salt

synthetic, ≥98.00% (TLC), Prednisolone derivative, lyophilized powder

别名:

6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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关于此项目

线性分子式:
C26H33O8Na
化学文摘社编号:
2375-03-3
分子量:
496.53
NACRES:
NA.77
PubChem Substance ID:
24896873
UNSPSC Code:
51111800
EC Number:
219-156-8
MDL number:
MFCD00152612
Assay:
≥98.00% (TLC)
Form:
lyophilized powder
Quality level:
100

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产品名称

6α-Methylprednisolone 21-hemisuccinate sodium salt, lyophilized powder

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

SMILES string

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

biological source

synthetic

sterility

non-sterile

assay

≥98.00% (TLC)

form

lyophilized powder

technique(s)

toxicology assay: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... NR3C1(2908)

相关类别

Application

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Physical form

Lyophilized containing ~5% phosphate buffer salts.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H351,H360

Hazard Classifications

Carc. 2 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN5669
BCCG3096
BCBZ8796
BCBW7102
SLBG7439V

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Basilar leptomeningitis in Vogt-Koyanagi-Harada disease.
Yince Loh
Neurology, 78(6), 438-439 (2012-02-09)
Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells
Zou W, et al.
Journal of Bone and Mineral Metabolism, 33(6), 615-624 (2015)
Matthias D'Hondt et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 69(3), 232-240 (2012-01-21)
The short-term stability of extemporaneously prepared triple intrathecal therapy, containing cytarabine, methotrexate sodium, and methylprednisolone sodium succinate, was evaluated. Three batches of triple intrathecal solution were prepared using commercially available products and stored in three different packaging materials (plastic syringe
Julio Urrutia et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 16(4), 439-442 (2011-04-30)
The effect of corticosteroids on spinal fusion healing has not yet been determined. To evaluate the effect of corticosteroids on lumbar spinal fusion we designed a randomized, placebo-controlled animal study using high-dose methylprednisolone sodium succinate, which is widely used in
Takaaki Kitakawa et al.
Documenta ophthalmologica. Advances in ophthalmology, 124(3), 249-254 (2012-03-10)
The purpose of this study was to report a patient with acute zonal occult outer retinopathy (AZOOR) unilaterally, who received steroid pulse therapy. A 42-year-old woman presented with photopsias and severe vision loss in her left eye. Visual acuity was
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