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Merck
CN

M7133

4-甲基伞形酮硫酸盐 钾盐

sulfatase substrate

别名:

4-甲基伞形基硫酸钾

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关于此项目

经验公式（希尔记法）:
C10H7KO6S
化学文摘社编号:
15220-11-8
分子量:
294.32
Beilstein:
3803203
EC 号:
239-272-2
MDL编号:
MFCD00016970
UNSPSC代码:
12352204
PubChem化学物质编号:
24897141
NACRES:
NA.32

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质量水平

200

方案

≥99% (HPLC)

表单

powder

溶解性

water: 5 mg/mL, clear, colorless

荧光

λex 334 nm; λem 370 nm (pH 10.4)
λex 360 nm; λem 449 nm (Reaction products)

储存温度

−20°C

SMILES字符串

[K+].CC1=CC(=O)Oc2cc(OS([O-])(=O)=O)ccc12

InChI

1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1

InChI key

CSOCSPXOODWGLJ-UHFFFAOYSA-M

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一般描述

4-甲基伞形酮硫酸酯（4MUS）作为一种通用底物，是4-甲基伞形酮（4MU）的极性代谢物。

应用

4-甲基伞形酮硫酸酯钾盐已用作偶联荧光硫代转移酶测定的底物，以从3′-磷酸腺苷5′-磷酸盐再生3′-磷酸腺苷 5′-磷酸硫酸盐（PAPS），进而测定脑苷脂硫酸转移酶（CST）的酶活性。它还用作芳香基硫酸酯酶测定/4-甲基伞形酮硫酸酯（4-MUS）测定的底物，以测试蛋白磁珠复合体的酶活性。

生化/生理作用

4-甲基伞形酮硫酸酯（4MUS）能够进行脱硫，并参与4MU的无效循环。它可以用于测定多种硫酸酯酶的活性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCQ6416
MKCL6250
MKCH2223
MKBV9175V
056K5007

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A M Hassen et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(7), 792-798 (1996-07-01)
The uptake of estrone sulfate (E1S; 1 to 400 microM), harmol sulfate (HS; 5 to 900 microM), and 4-methylumbelliferyl sulfate (4MUS; 5 to 1000 microM) was investigated in isolated rat hepatocytes in the presence or absence of inhibitors. Uptake of
O P van Diggelen et al.
Journal of inherited metabolic disease, 12(3), 273-280 (1989-01-01)
Arylsulphatase C (ASC) activity in leukocytes and fibroblasts measured with 4-methylumbelliferylsulphate, is caused by at least two genetically different sulphatases. One of these is steroid sulphatase (STS). Depending on the substrate concentration, about 10-50% of the ASC activity in leukocytes
J Chen et al.
The Journal of pharmacology and experimental therapeutics, 280(1), 24-31 (1997-01-01)
The vascularly perfused rat intestine and liver preparations were used to examine the effect of flow (8 and 10 ml/min) on the sequential metabolism of 4-methylumbelliferone (4MU), which forms primarily the glucuronide conjugate (4MUG) in intestine and the sulfate conjugate
C L Zimmerman et al.
Journal of chromatography, 563(1), 83-94 (1991-01-18)
A direct high-performance liquid chromatographic (HPLC) assay was developed for the separation and determination of 4-methylumbelliferone (4MU) and its glucuronide (MUG) and sulfate (MUS) conjugates in the cell-free perfusate ("plasma") from in situ perfused rat intestine-liver preparation. In addition, a
Lihua Wang-Eckhardt et al.
Cells, 10(12) (2021-12-25)
Sulfatide synthesis in the human renal cancer cell line SMKT-R3 was strongly inhibited in the presence of low µM concentrations of AG-205, a progesterone receptor membrane component 1 (PGRMC1) antagonist. This was also the case in Chinese hamster ovary (CHO)
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Drug Conjugate Analysis using β-Glucuronidases

Drug conjugate analysis and the enzymatic hydrolysis of glucuronides

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