Merck
CN
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文件

M8515

Sigma-Aldrich

莫纳托

≥98% (HPLC), solid

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别名:
4-（3-羟基苯基）-6-甲基-2-硫氧-1,2,3,4-四氢-4H-嘧啶-5-羧酸乙酯
经验公式（希尔记法）:
C14H16N2O3S
CAS号:
254753-54-3
分子量:
292.35
MDL编号:
MFCD00813077
PubChem化学物质编号:
24897267
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

储存条件

protect from light

颜色

white to off-white

mp

185-185.9 °C (lit.)

溶解性

DMSO: >5 mg/mL

储存温度

2-8°C

SMILES string

CCOC(=O)C1=C(C)NC(=S)NC1c2cccc(O)c2

InChI

1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)

InChI key

LOBCDGHHHHGHFA-UHFFFAOYSA-N

应用

Monastrol已被用于：
  • 将MDA-MB-231细胞作为非微管靶向剂
  • 作为抗肿瘤剂，治疗小鼠骨髓瘤细胞系SP 2/0，诱导细胞凋亡并阐明代谢型谷氨酸受体3（Grm3）在凋亡中的作用-作为蝶呤还原酶抑制剂在GFP转染的前鞭毛体巨噬细胞中的作用
  • 用于基于流式细胞仪的生长抑制试验并评价利什曼原虫仓鼠体内模型的抗利什曼活性

生化/生理作用

Monastrol 是一种强效、细胞渗透的有丝分裂抑制剂。Monastrol 阻滞细胞的特征是单极纺锤体。该表型是通过用 IC 50 在 14μM的浓度下特异性破坏有丝分裂分子马达驱动蛋白 Eg5 而诱导的。对其他马达蛋白和微管蛋白无影响。

特点和优势

这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

包装

在惰性气体下包装。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis
Liu X, et al.
International journal of oncology, 49(4), 1469-1478 (2016)
M410, a combretastatin A4 analogue, disrupts microtubules and inhibits HIF-1 alpha in human breast cancer cells
Yang H, et al.
Oncology Reports, 34(1), 334-340 (2015)
Rebecca A Holton et al.
Biology of reproduction, 103(1), 24-35 (2020-03-29)
The number and quality of oocytes, as well as the decline in both of these parameters with age, determines reproductive potential in women. However, the underlying mechanisms of this diminution are incompletely understood. Previously, we identified novel roles for CHTF18
Renske van Leuken et al.
PloS one, 4(4), e5282-e5282 (2009-04-25)
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also
Steven Haney et al.
PloS one, 8(6), e64946-e64946 (2013-07-11)
Genome-wide association (GWA) studies have described a large number of new candidate genes that contribute to of Type 2 Diabetes (T2D). In some cases, small clusters of genes are implicated, rather than a single gene, and in all cases, the
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