M9020
美加明 盐酸盐
≥98% (TLC), powder, nAChR antagonist
别名:
2-（甲氨基）异樟烷 盐酸盐, N,2,3,3-四甲基二环 [2.2.1] 庚烷-2-胺 盐酸盐, 盐酸美加明
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关于此项目
经验公式（希尔记法）:
C11H21N · HCl
化学文摘社编号:
分子量:
203.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
212-555-8
MDL number:
Form:
powder
Quality level:
产品名称
美加明 盐酸盐,
InChI key
PKVZBNCYEICAQP-CIISUUNXSA-N
InChI
1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
SMILES string
Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C
form
powder
solubility
ethanol: 122 mg/mL, H2O: 47 mg/mL, isopropanol: 476 mg/mL, glycerol: 95 mg/mL
originator
AstraZeneca
Quality Level
Gene Information
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相关类别
Application
在电流钳记录期间，美卡拉明盐酸盐已被用作细胞外盐水中的添加剂以减少突触输入。它还被用作主动脉体神经元和 MLO-Y4 细胞中的非选择性烟碱乙酰胆碱受体阻断剂。
Biochem/physiol Actions
非竞争性烟碱乙酰胆碱受体拮抗剂；优先阻断自主神经节的烟碱受体；穿过血脑屏障。
Features and Benefits
该化合物在受体分类和信号转导手册的乙酰胆碱受体（烟碱型）页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物由 AstraZeneca 公司开发。若要浏览其他制药公司研发的化合物和批准的药物/候选药物列表，请单击此处。
Disclaimer
溶液在高压灭菌时稳定。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Pharmacological mechanisms involved in nicotine-induced seizures were investigated in mice by testing the ability of several nicotinic agonists in producing seizures after peripheral administration. In addition, nicotinic antagonists such as hexamethonium, mecamylamine, dihydro-beta-erythroidine, and methyllycaconitine citrate (MLA) were used in
G Panagis et al.
Synapse (New York, N.Y.), 35(1), 15-25 (1999-12-01)
In the present study the neuronal expression of Fos, the protein product of c-fos, was used to study changes in neuronal activity in nerve terminal regions of the ascending dopaminergic system during nicotine withdrawal. Rats were infused for 14 days
Acetylcholine affects osteocytic MLO-Y4 cells via acetylcholine receptors
Ma Y, et al.
Molecular and cellular endocrinology, 384(1-2), 155-164 (2014)
Potential roles of ATP and local neurons in the monitoring of blood O2 content by rat aortic bodies
Piskuric NA, et al.
Experimental Physiology, 99(1), 248-261 (2014)
Olena Riabinina et al.
Genetics, 212(1), 53-63 (2019-03-14)
The Q-system is a binary expression system that works well across species. Here, we report the development and demonstrate the applications of a split-QF system that drives strong expression in Drosophila, is repressible by QS, and is inducible by a
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