N144
尼群地平
>95%, powder
别名:
1,4-二氢-2,6-二甲基-4-(3-硝基苯)-3,5-吡啶二羧酸乙基甲酯
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关于此项目
经验公式（希尔记法）:
C18H20N2O6
化学文摘社编号:
分子量:
360.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
254-513-1
MDL number:
产品名称
尼群地平, >95%, powder
InChI key
PVHUJELLJLJGLN-UHFFFAOYSA-N
InChI
1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
SMILES string
CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC
assay
>95%
form
powder
color
yellow to green
solubility
methanol: 15 mg/mL
DMSO: 17.5 mg/mL
H2O: insoluble
Quality Level
Gene Information
human ... ADORA3(140), CACNG1(786), KCNH1(3756), TTR(7276)
rat ... Adora1(29290), Adora2a(25369)
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相关类别
Biochem/physiol Actions
Ca2+ channel blocker; anti-hypertensive.
存储类别
11 - Combustible Solids
wgk
WGK 1
ppe
dust mask type N95 (US), Eyeshields, Gloves
Dengning Xia et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 446-454 (2012-04-10)
The amorphous-to-crystalline transformation of nitrendipine was investigated using Raman spectroscopy and X-ray powder diffraction (XRPD). The nucleation and growth rate of crystalline nitrendipine in a medium containing poly (vinyl alcohol) (PVA) and polyethylene glycol (PEG 200) were quantitatively determined using
Yanhua Liu et al.
Arzneimittel-Forschung, 61(12), 674-680 (2012-01-28)
A rapid, sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of nitrendipine (NTD, CAS 39562-70-4) in dog plasma. Using propranolol hydrochloride (CAS 318-98-9) as an internal standard (IS), plasma samples
Peng Quan et al.
International journal of pharmaceutics, 430(1-2), 366-371 (2012-04-26)
In this study, chitosan, a cationic polymer with positive charge, was introduced to modify the nanocrystals of nitrendipine with negative charge. The nanocrystals were prepared via precipitation-high pressure homogenization method. Then the nanocrystals were dispersed into chitosan solution, and the
Dewei Shang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(30), 3459-3464 (2011-10-05)
A HPLC method with on-line solid phase extraction (SPE) and DAD detection was developed for the simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat (SHR) plasma. Plasma samples (100 μL) were injected directly onto a CAPCELL MF C(8)
Peng Quan et al.
AAPS PharmSciTech, 12(4), 1136-1143 (2011-09-06)
The present investigation was undertaken with the objective of developing a solid formulation containing nitrendipine nanocrystals for oral delivery. Nitrendipine nanocrystals were prepared using a tandem precipitation-homogenization process. Then, spray drying, a cost-effective method very popular in industrial situations, was
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