O3636
1H-[1,2,4]恶二唑并[4,3-a]喹恶啉-1-酮
powder
别名:
ODQ
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选择尺寸
关于此项目
经验公式（希尔记法）:
C9H5N3O2
化学文摘社编号:
分子量:
187.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
1H-[1,2,4]恶二唑并[4,3-a]喹恶啉-1-酮, powder
Quality Level
InChI
1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
SMILES string
O=C1ON=C2C=Nc3ccccc3N12
InChI key
LZMHWZHOZLVYDL-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
color
pale yellow
solubility
ethanol: 1.2 mg/mL
DMSO: 5 mg/mL
H2O: insoluble
storage temp.
2-8°C
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
相关类别
Application
1H-[1,2,4]恶二唑[4,3-a]喹喔啉-1-酮已被用作亲和选择质谱 (AS-MS) 化合物结合检测中的氧化剂 作为可溶性鸟苷酸环化酶 (sGC) 抑制剂用于抑制S-亚硝基-N-乙酰基-DL-青霉胺 (SNAP) 诱导的cGMP生产。
Biochem/physiol Actions
H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮（ODQ）能够非竞争性地抑制一氧化氮敏感性鸟苷酸环化酶的作用，并且可能导致血红素辅基发生不可逆氧化。 ODQ已被用于研究环磷酸鸟苷（cGMP）途径在一氧化氮（NO）信号转导中的作用。
一氧化氮敏感性鸟苷酸环化酶的选择性抑制剂。
Disclaimer
吸湿
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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