O3639
昂丹司琼 盐酸盐 二水合物
≥98% (HPLC), powder, 5-HT₃serotonin receptor antagonist
别名:
1,2,3,9-四氢-9-甲基-3-[（2-甲基-1H-咪唑-1-基）甲基] -4H-咔唑-4-酮 盐酸盐, GR 38032F
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关于此项目
经验公式（希尔记法）:
C18H19N3O · HCl · 2H2O
化学文摘社编号:
分子量:
365.85
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
昂丹司琼 盐酸盐 二水合物, ≥98% (HPLC), powder
SMILES string
Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C
InChI key
VRSLTNZJOUZKLX-UHFFFAOYSA-N
InChI
1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: >5 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... HTR3A(3359)
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相关类别
Application
恩丹西酮盐酸盐二水合物已用作 5-HT3 拮抗剂，用于减弱 延髓吻段腹内侧部（RVM）/缩胆囊素（CCK）诱导的机械超敏反应，并用于阻断曲古抑菌素 A（TSA）对 5-HT3 蛋白的作用。
Biochem/physiol Actions
5-HT3 血清素受体拮抗剂
昂丹司琼，（3RS）-9-甲基-3-[（2-甲基-1H-咪唑-1-基）甲基] 1,2,3,9-四氢-4H-咔唑-4-酮盐酸盐脱水剂作为选择性 5-羟色胺 3 型（5-HT3）5-羟色胺受体拮抗剂。它被用作止吐剂，控制与化疗和放疗相关的恶心和呕吐。
Features and Benefits
该化合物由 GlaxoSmithKline 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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Alcohol-induced serotonergic modulation: the role of histone deacetylases
Agudelo M
Alcohol, 46(7), 635-642 (2012)
Global experience with ondansetron and future potential.
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Oncology, 50(3), 191-197 (1993)
Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E2 in the spinal cord.
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Pain, 153(1), 86-94 (2012)
ION-PAIR REVERSED-PHASE HIGHPERFORMANCE
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SODIUM HEPTANESULPHONATE AS A
COUNTERION
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varvara A
Farmacia, 57, 4, 442-451 (2009)
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