O8382
17-十八炔酸
≥95% (GC), Cytochrome P450 epoxygenase inhibitor, powder
别名:
17-ODYA, Alkynyl Stearic Acid, Octadec-17-ynoic acid
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H32O2
化学文摘社编号:
分子量:
280.45
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
17-十八炔酸, ≥95% (GC)
SMILES string
C#CCCCCCCCCCCCCCCCC(O)=O
InChI
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h1H,3-17H2,(H,19,20)
InChI key
DZIILFGADWDKMF-UHFFFAOYSA-N
assay
≥95% (GC)
form
powder
solubility
chloroform: 10 mg/mL to clear, colorless to faintly yellow
Quality Level
Application
17-十八炔酸可用于脂质合成。
Biochem/physiol Actions
17-十八炔酸 (7-ODYA) 是细胞色素P450同工酶的不可逆抑制剂，参与长链脂肪酸代谢。
选择性和不可逆地抑制细胞色素 P450 环氧酶和 ω-水解酶的自杀底物抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M H Wang et al.
The Journal of pharmacology and experimental therapeutics, 284(3), 966-973 (1998-03-13)
We characterized the inhibitory activity of several acetylenic and olefinic compounds on cytochrome P450 (CYP)-derived arachidonic acid omega-hydroxylation and epoxidation using rat renal cortical microsomes and recombinant CYP proteins. Among the acetylenic compounds, 6-(2-propargyloxyphenyl)hexanoic acid (PPOH) and N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide were found
Lu Wei et al.
Nature methods, 11(4), 410-412 (2014-03-04)
Sensitive and specific visualization of small biomolecules in living systems is highly challenging. We report stimulated Raman-scattering imaging of alkyne tags as a general strategy for studying a broad spectrum of small biomolecules in live cells and animals. We demonstrate
Mamta Fuloria et al.
American journal of physiology. Lung cellular and molecular physiology, 283(2), L383-L389 (2002-07-13)
We examined the responses of newborn piglet pulmonary resistance arteries (PRAs) to 5,6-epoxyeicosatrienoic acid (5,6-EET), a cytochrome P-450 metabolite of arachidonic acid. In PRAs preconstricted with a thromboxane A(2) mimetic, 5,6-EET caused a concentration-dependent dilation. This dilation was partially inhibited
Effects of intrarenal infusion of 17-octadecynoic acid on renal antihypertensive mechanisms in anesthetized rabbits
Evans R G, et al.
American Journal of Hypertension, 11(7), 803-812 (1998)
Ossama A Hatoum et al.
American journal of physiology. Heart and circulatory physiology, 288(1), H48-H54 (2004-09-04)
The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several mediators of vasodilation, which include prostacyclin (PGI(2)), nitric oxide, and endothelium-derived hyperpolarizing factor (EDHF). We have recently defined the role of nitric oxide and PGI(2)
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