P0689
(R)-(+)-普奈洛尔 盐酸盐
≥98% (TLC), Beta-adrenergic antagonist
别名:
(R)-1-(异丙基氨基)-3-(1-萘氧基)-2-丙醇 盐酸盐
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关于此项目
线性分子式:
C10H7OCH2CH(OH)CH2NHCH(CH3)2·HCl
化学文摘社编号:
分子量:
295.80
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
235-961-7
MDL number:
Beilstein/REAXYS Number:
5780490
产品名称
(R)-(+)-普奈洛尔 盐酸盐, ≥98% (TLC)
InChI key
ZMRUPTIKESYGQW-PFEQFJNWSA-N
InChI
1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m1./s1
SMILES string
Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12
assay
≥98% (TLC)
mp
196-198 °C (lit.)
solubility
ethanol: 10 mg/mL
DMSO: <14.5 mg/mL
H2O: 50 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
普奈洛尔活性较低的对映体。
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Montserrat Solé et al.
Analytical and bioanalytical chemistry, 396(2), 649-656 (2009-10-20)
Environmental risk assessments of human pharmaceuticals and other 'emerging contaminants' should integrate both population-relevant endpoints and biomarkers of potential modes of action in a range of species. Adult Mytilus galloprovincialis were exposed to the beta-adrenergic receptor blocker propranolol or to
Silvia Gramolelli et al.
Cancer research, 80(15), 3116-3129 (2020-06-11)
Kaposi sarcoma is a tumor caused by Kaposi sarcoma herpesvirus (KSHV) infection and is thought to originate from lymphatic endothelial cells (LEC). While KSHV establishes latency in virtually all susceptible cell types, LECs support spontaneous expression of oncogenic lytic genes
Jieyu Xu et al.
Toxicology in vitro : an international journal published in association with BIBRA, 48, 286-301 (2018-02-07)
Immortalized liver cells have been used for evaluating the toxicity of compounds; however, excessive glutathione is considered to lessen cytotoxicity. In this study, we compared the effects of glutathione depletion on cytotoxicities of drugs using HepaRG and HepG2 cells, which
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