Merck
CN
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安全信息

P1784

Sigma-Aldrich

己酮可可碱

solid

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别名:
3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
经验公式（希尔记法）:
C13H18N4O3
CAS号:
6493-05-6
分子量:
278.31
EC 号:
229-374-5
MDL编号:
MFCD00063379
PubChem化学物质编号:
24278190

形式

solid

质量水平

100

颜色

white

溶解性

H2O: ≥43 mg/mL, colorless to almost colorless

创始人

Sanofi Aventis

SMILES string

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI key

MQGNNJQTNFHNHK-UHFFFAOYSA-N

Gene Information

human ... ADORA2B(136) , LITAF(9516) , PDE4B(5142) , TNF(7124)
rat ... Tnf(24835)

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应用

Pentoxifylline has been used:
  • used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
  • to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
  • to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

生化/生理作用

Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

特点和优势

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice
Naranjo T W, et al.
Pulmonary Pharmacology & Therapeutics, 24(1), 81-91 (2011)
Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis
Fernandez-Zafra T, et al.
Pain, 160(1), 224-224 (2019)
Pentoxifylline Enhances the Apoptotic Effect of Carboplatin in Y79 Retinoblastoma Cells
CRUZ-GALVEZ C C, et al.
In Vivo, 33(2), 401-412 (2019)
Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons
Donate-Correa J T, et al.
Journal of clinical medicine, 8(3), 287-287 (2019)
Xinfang Huang et al.
Cellular & molecular immunology, 18(4), 969-978 (2021-03-13)
T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poorly understood. Here, through two mixed bone marrow chimeric experiments, we identified Peli1, a
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