P1784
己酮可可碱
Phosphodiesterase inhibitor, solid
别名:
3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
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关于此项目
经验公式（希尔记法）:
C13H18N4O3
化学文摘社编号:
分子量:
278.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
229-374-5
MDL number:
产品名称
己酮可可碱, solid
InChI key
MQGNNJQTNFHNHK-UHFFFAOYSA-N
InChI
1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
SMILES string
CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
form
solid
color
white
solubility
H2O: ≥43 mg/mL, colorless to almost colorless
originator
Sanofi Aventis
Quality Level
Gene Information
human ... ADORA2B(136), LITAF(9516), PDE4B(5142), TNF(7124)
rat ... Tnf(24835)
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Application
Pentoxifylline has been used:
- used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
- to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
- to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour
Biochem/physiol Actions
Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Lact.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Pentoxifylline in the Treatment of Cutaneous Leishmaniasis: A Randomized Clinical Trial in Colombia.
Maria Del Mar Castro et al.
Pathogens (Basel, Switzerland), 11(3) (2022-03-27)
Addition of the immunomodulator pentoxifylline (PTX) to antimonial treatment of mucosal leishmaniasis has shown increased efficacy. This randomized, double-blind, placebo-controlled trial evaluated whether addition of pentoxifylline to meglumine antimoniate (MA) treatment improves therapeutic response in cutaneous leishmaniasis (CL) patients. Seventy-three
PP-023-Effect of ICSI with `pentoxifylline exposed sperms? on subsequent embryo development
Mangoli V S, et al.
Reproductive Biomedicine Online, 32, S11-S11 (2016)
B K Reuter et al.
The American journal of physiology, 277(4 Pt 1), G847-G854 (1999-10-12)
Although the ability of nonsteriodal anti-inflammatory drugs (NSAIDs) to injure the small intestine has been well established in humans and animals, the mechanism involved in this type of injury has yet to be elucidated. The cytokine tumor necrosis factor-alpha (TNF-alpha)
Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons
Donate-Correa J T, et al.
Journal of clinical medicine, 8(3), 287-287 (2019)
Xinfang Huang et al.
Cellular & molecular immunology, 18(4), 969-978 (2021-03-13)
T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poorly understood. Here, through two mixed bone marrow chimeric experiments, we identified Peli1, a
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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