P3510
罂粟碱 盐酸盐
≥98% (titration by HCL04), powder, cerebral vasodilator
别名:
6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
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关于此项目
经验公式（希尔记法）:
C20H21NO4 · HCl
化学文摘社编号:
分子量:
375.85
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-502-1
MDL number:
Beilstein/REAXYS Number:
3921435
产品名称
罂粟碱 盐酸盐, powder
InChI key
UOTMYNBWXDUBNX-UHFFFAOYSA-N
InChI
1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
SMILES string
COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl
assay
≥98%
form
powder
color
white
solubility
H2O: 25 mg/mL
Quality Level
Gene Information
human ... PDE4B(5142)
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Application
Papaverine hydrochloride has been used:
- in oxygenated Krebs solution for tissue mechanics analysis
- as a vasodilator in heparinized horse serum in tissue uptake technique
- as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat
Biochem/physiol Actions
Papaverine is originally used to resolve male impotence.
Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells
Grundemann D, et al.
British Journal of Pharmacology, 137(6), 910-918 (2002)
Increased glomerular albumin permeability in old spontaneously hypertensive rats
Bakoush O, et al.
Nephrology, Dialysis, and Transplantation, 19(7), 1724-1731 (2004)
Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage
Liu James K and Couldwell William T
Neurocritical Care, 2(2), 124-132 (2005)
Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice
Suen RS, et al.
The American Journal of Pathology, 179(3), 1549-1559 (2011)
Effects of antiallergic agents, compound 48/80, and some reference inhibitors on the activity of partially purified human lung tissue adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate phosphodiesterases.
H Bergstrand et al.
Molecular pharmacology, 13(1), 38-43 (1977-01-01)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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