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P6500

Sigma-Aldrich

戊四唑

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别名:
1,5-五亚甲基-1H-四唑, 6,7,8,9-四氢-5H-四唑并氮杂卓, 戊四氮, 戊撑四唑
经验公式（希尔记法）:
C6H10N4
CAS号:
54-95-5
分子量:
138.17
EC 号:
200-219-3
MDL编号:
MFCD00005939
PubChem化学物质编号:
24278643
NACRES:
NA.77

形式

powder

质量水平

100

bp

194 °C/12 mmHg (lit.)

mp

59-61 °C (lit.)

储存温度

−20°C

SMILES string

C1CCc2nnnn2CC1

InChI

1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2

InChI key

CWRVKFFCRWGWCS-UHFFFAOYSA-N

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一般描述

戊四唑（PTZ）为四唑衍生物，是γ氨基丁酸（GABAA）及其受体复合物的抑制剂。 PTZ是用于诱发惊厥的惊厥剂。可穿透血脑屏障。

应用

戊四唑用于诱发斑马鱼幼虫 、小鼠 和雄性Wistar大鼠发生惊厥。

生化/生理作用

戊四唑是非特异性中枢神经系统（CNS）兴奋剂和惊厥剂。PTZ诱发氧化应激，增加皮质内丙二醛含量并影响海马体功能，导致发生惊厥。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书(COA)

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示例

T1503
货号
-
25G
包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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  • 如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。

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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How do I solubilize Product P6500, Pentylenetetrazole?

    We test the solubility of this compound at a concentration of 50 mg/mL in water.

  6. What is the solution stability for Product P6500, Pentylenetetrazole?

    We do not have any solution stability information for this product.  It is always best to make a fresh solution. If this is not possible, you can try storing solution in single use aliquots at -20°C.

  7. Can Product P6500, Pentylenetetrazole, be used to induce convulsions?

    Pentylenetetrazole induced convulsions have been reported by De Sarro G. et al., in Eur. J. Pharmacol., 368(2-3),149-159 (1999).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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