P7903
吡哌酸
别名:
8-乙基-5,8-二氢-5-氧-2-(1-哌嗪基)吡啶并(2,3-d)嘧啶-6-羧酸
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关于此项目
经验公式（希尔记法）:
C14H17N5O3
化学文摘社编号:
分子量:
303.32
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51282938
EC Number:
257-530-2
MDL number:
InChI key
JOHZPMXAZQZXHR-UHFFFAOYSA-N
InChI
1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)
SMILES string
CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3
form
powder
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
DNA synthesis | interferes
cell wall synthesis | interferes
enzyme | inhibits
Gene Information
human ... CYP1A2(1544)
Analysis Note
在水中极微溶解。它溶于酸和碱金属氢氧化物的稀释溶液。
Application
吡哌酸被用于研究DNA损伤和诱变活性。它已被用于诱导新生小鼠的关节病变，并用于研究人淋巴细胞胚细胞生成和干扰素的产生。
Biochem/physiol Actions
吡哌酸可调节（抑制）细菌DNA促旋酶依赖性过程，如DNA聚合、（ATP依赖性）DNA超螺旋和染色体断裂。已有研究显示，吡哌酸可诱导淋巴细胞DNA合成的抑制。
General description
化学结构：喹诺酮
Other Notes
10g,100g
保持容器密封，存放在干燥，通风良好的地方。保持干燥
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
D A Schmid et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 36(1), 59-69 (2006-01-06)
Quinolones are widely used, broad spectrum antibiotics that can induce immediate- and delayed-type hypersensitivity reactions, presumably either IgE or T cell mediated, in about 2-3% of treated patients. To better understand how T cells interact with quinolones, we analysed six
Margherita Lavorgna et al.
International journal of molecular sciences, 20(2) (2019-01-24)
Pipemidic acid (HPPA) is a quinolone antibacterial agent used mostly to treat gram-negative infections of the urinary tract, but its therapeutic use is limited because of its low solubility. Thus, to improve drug solubility, natural cyclodextrins (CDs) are used for
Yao-Dong Liang et al.
Analytical and bioanalytical chemistry, 380(7-8), 918-923 (2004-11-30)
A flow-injection chemiluminescence (CL) method for the determination of pipemidic acid is described. It is based on energy transfer from excited state peroxynitrous acid to pipemidic acid, in which the excited state peroxynitrous acid is synthesized on-line by the mixing
Juan Li et al.
Environmental health perspectives, 120(8), 1144-1149 (2012-05-10)
Inappropriate use of antibiotics in swine feed could cause accelerated emergence of antibiotic resistance genes, and agricultural application of swine waste could spread antibiotic resistance genes to the surrounding environment. We investigated the distribution of plasmid-mediated quinolone resistance (PMQR) genes
Jin Sun et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 64(2), 238-245 (2006-08-01)
This study described distribution characteristics of olamufloxacin (HSR-903) in lung epithelial lining fluid (ELF) and alveolar macrophage (AM) in rats, two important representative infectious sites in lower respiratory tract infections. The rats were orally administered at a dose of 10mg/kg.
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