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文件

P9767

Sigma-Aldrich

棕榈酸钠

≥98.5%

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别名:
十六烷酸 钠盐, 棕榈酸 钠盐
线性分子式:
CH3(CH2)14COONa
CAS号:
408-35-5
分子量:
278.41
Beilstein:
3575882
EC 号:
206-988-1
MDL编号:
MFCD00002749
PubChem化学物质编号:
24899061
NACRES:
NA.25

生物来源

plant (palm)

质量水平

200

检测方案

≥98.5%

形式

powder

mp

283-290 °C (lit.)

官能团

ester

lipid type

saturated FAs

运输

ambient

储存温度

2-8°C

SMILES string

[Na+].CCCCCCCCCCCCCCCC([O-])=O

InChI

1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1

InChI key

GGXKEBACDBNFAF-UHFFFAOYSA-M

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应用

棕榈酸钠（PA）已被用于：
  • 通过蛋白质免疫印迹和细胞活性MTT测定证明，PA通过激活活性氧（ROS）产生、Janus激酶（JNK）信号传导和组蛋白H3释放，诱导小鼠巨噬细胞RAW 264.7的炎症和血栓形成途径
  • 通过蛋白质免疫印迹和定量PCR分析，利用PA诱导AML12细胞和原代肝细胞的脂肪生成，进而分析鸢尾苷对PA诱导的脂肪生成及相关信号通路的影响
  • 作为游离脂肪酸混合物的成分，诱导HepG2细胞的细胞脂肪变性，并通过油红O染色测定脂质积累

生化/生理作用

棕榈酸钠是棕榈酸的钠盐，它是硬皂的成分。棕榈酸是一种常见的饱和脂肪酸，是在脂肪酸合成过程中产生的。棕榈酸钠可增强各种细胞中的脂肪生成、 细胞脂肪变性。棕榈酸可增强脂肪酸积累，从而诱导人表皮生长因子受体2（HER2）/neu阳性细胞和乳腺癌细胞(如MCF-7)的死亡。棕榈酸钠通过诱导糖原合酶激酶-3β(GSK3β)表达，进而诱导L02和HepG2肝细胞的脂性凋亡。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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示例

T1503
货号
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25G
包装规格/数量

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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I dissolve Sodium palmitate, Product P9767?

    We test the solubility in methanol at 50 mg/mL.

  4. How do I dissolve Sodium palmitate, Product P9767?

    Sodium palmitate does not dissolve readily in methanol at room temperature.  We test the solubility by heating it for up to 15 minutes to get a clear, colorless solution. Note that the boiling point of methanol is approximately 65°C.

  5. How do I store Sodium palmitate, Product P9767, as provided?

    This compound is stable for years at 2-8°C.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

José M S Fernández-Calleja et al.
Scientific reports, 9(1), 11507-11507 (2019-08-10)
Indirect calorimetry (InCa) estimates whole-body energy expenditure and total substrate oxidation based on O2 consumption and CO2 production, but does not allow for the quantification of oxidation of exogenous substrates with time. To achieve this, we incorporated 13CO2 and 12CO2
Metabolic assays for detection of neutral fat stores
Baumann JM, et al.
Bio-protocol, 90(5), 20-20 (2015)
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3 beta activation in human liver cells
Cao J, et al.
Digestive Diseases and Sciences, 59(2), 346-357 (2014)
Nicolas J Pillon et al.
Cell communication and signaling : CCS, 10(1), 30-30 (2012-10-20)
Obesity is associated with chronic low-grade inflammation. Within adipose tissue of mice fed a high fat diet, resident and infiltrating macrophages assume a pro-inflammatory phenotype characterized by the production of cytokines which in turn impact on the surrounding tissue. However
Linnéa Eriksson et al.
Cardiovascular diabetology, 11, 27-27 (2012-03-23)
The leading cause of death for patients suffering from diabetes is macrovascular disease. Endothelial dysfunction is often observed in type 2 diabetic patients and it is considered to be an important early event in the pathogenesis of atherogenesis and cardiovascular
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