PHG0005
BIS-TRIS丙烷
别名:
1,3-双[三(羟甲基)甲氨基]丙烷
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线性分子式:
CH2[CH2NHC(CH2OH)3]2
化学文摘社编号:
分子量:
282.33
EC Number:
264-899-3
UNSPSC Code:
12161705
NACRES:
NA.21
Beilstein/REAXYS Number:
1786109
MDL number:
biological source
synthetic
Quality Level
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
Endotoxin, microbial, and trace metals; tested
useful pH range
6.3-9.5
pKa (25 °C)
(1) 6.8, (2) 9.0
mp
164-165 °C (lit.)
suitability
suitable for manufacturing use
foreign activity
Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
SMILES string
OCC(CO)(CO)NCCCNC(CO)(CO)CO
InChI
1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2
InChI key
HHKZCCWKTZRCCL-UHFFFAOYSA-N
General description
我们用于生物制药加工的SAFC®系列优质原料经过严格的质量控制流程，配合记录文件和技术专长帮助我们的客户达到M-Clarity 计划规定的要求
M-Clarity 计划
缓冲液质量是生物制药工艺成功的关键，因为缓冲液几乎在每一个生产步骤中都是必不可少的。
我们广泛的缓冲材料产品线经过妥善管控，可根据您的需求量身定制。从低风险应用的非 GMP 等级，到高风险应用的 IPEC-PQG GMP标准，我们的产品可满足您的所有制造需求。
M-Clarity 计划
缓冲液质量是生物制药工艺成功的关键，因为缓冲液几乎在每一个生产步骤中都是必不可少的。
我们广泛的缓冲材料产品线经过妥善管控，可根据您的需求量身定制。从低风险应用的非 GMP 等级，到高风险应用的 IPEC-PQG GMP标准，我们的产品可满足您的所有制造需求。
Application
Bis Tris丙烷是一种独特的生物缓冲液，也可称为“通用型”缓冲液，因为它的缓冲范围很广。Bis Tris丙烷有两个pKa值，6.3和9.5，所以缓冲范围扩展到5.0-10.5，在生物体系中用途广泛。Bis Tris丙烷对培养细胞无毒，并具有高溶液澄清度。
一篇关于DNA聚合酶技术的综述因Bis Tris丙烷宽广的缓冲pH梯度而将其列为适合PCR的缓冲液。
一篇关于DNA聚合酶技术的综述因Bis Tris丙烷宽广的缓冲pH梯度而将其列为适合PCR的缓冲液。
Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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