S0127
磺胺噻唑 钠盐
≥99%
别名:
4-氨基-N-（2-噻唑基）苯磺酰胺 钠盐
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关于此项目
经验公式（希尔记法）:
C9H8N3NaO2S2
化学文摘社编号:
分子量:
277.30
UNSPSC Code:
51283955
NACRES:
NA.85
PubChem Substance ID:
EC Number:
205-638-5
Beilstein/REAXYS Number:
3802297
MDL number:
biological source
synthetic (Organic)
assay
≥99%
form
powder
color
white to off-white
solubility
H2O: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
Nc1ccc(cc1)S(=O)(=O)N([Na])c2nccs2
InChI
1S/C9H8N3O2S2.Na/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;/h1-6H,10H2;/q-1;+1
InChI key
GWIJGCIVKLITQK-UHFFFAOYSA-N
General description
化学结构：磺胺
Application
磺胺噻唑是一种短效磺胺药。在发现毒性较低的替代品之前，它是一种常见的口服和外用抗生素。它不再用于人类。在实验动物的饮食中加入磺胺噻唑可抑制肠道细菌形成叶酸。这确保了动物可用叶酸的唯一来源是它们的饮食。
Biochem/physiol Actions
磺胺噻唑是一种磺胺类抗生素，通过抑制二氢丙酸合成酶来阻断二氢叶酸的合成。磺胺噻唑是细菌对氨基苯甲酸（PABA）的竞争性抑制剂，它是细菌合成叶酸所必需的。它对革兰氏阳性细菌、革兰氏阴性细菌和衣原体均具有抗性。抗性产生机制是通过改变二氢蝶酸合成酶或叶酸合成的替代途径。
Other Notes
保存于密闭容器内，置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
Aron M Troen et al.
The Journal of nutrition, 138(12), 2502-2509 (2008-11-22)
Poor folate status is associated with cognitive decline and dementia in older adults. Although impaired brain methylation activity and homocysteine toxicity are widely thought to account for this association, how folate deficiency impairs cognition is uncertain. To better define the
Yun Hu et al.
Journal of pharmaceutical and biomedical analysis, 53(3), 412-420 (2010-07-08)
The simultaneous quantitative analysis of sulfathiazole polymorphs (forms I, III and V) in ternary mixtures by attenuated total reflectance-infrared (ATR-IR), near-infrared (NIR) and Raman spectroscopy combined with multivariate analysis is reported. To reduce the effect of systematic variations, four different
Merle K Richter et al.
Environmental pollution (Barking, Essex : 1987), 172, 208-215 (2012-10-16)
The effects of sulfathiazole (STA) on Escherichia coli with glucose as a growth substrate was investigated to elucidate the effect-based reaction of sulfonamides in bacteria and to identify biomarkers for bacterial uptake and effect. The predominant metabolite was identified as
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S0127-500G | 04061835534401 |
| S0127-100G | 04061836830014 |
| S0127-1KG | 04061835534388 |
| S0127-250G | 04061835534395 |