S4526

盐霉素

Name: 盐霉素
Brand: SIGMA

from Streptomyces albus, ≥98% (HPLC), powder, MDRP-1 inhibitor

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About This Item

经验公式（希尔记法）:

C₄₂H₇₀O₁₁

CAS Number:

53003-10-4

分子量:

751.00

EC 号:

258-290-1

UNSPSC代码:

12352200

PubChem化学物质编号:

329824546

NACRES:

NA.77

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Product Name

盐霉素, from Streptomyces albus, ≥98% (HPLC)

生物来源

Streptomyces albus

质量水平

200

方案

≥98% (HPLC)

mp

112.5-113.5 °C (lit.)

抗生素抗菌谱

neoplastics

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES字符串

CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2O[C@@]3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(O)=O

InChI

1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1

InChI key

KQXDHUJYNAXLNZ-XQSDOZFQSA-N

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一般描述

Chemical structure: polyether

应用

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44⁺CD24^- mesenchymal-like subpopulation within breast carcinomas.

生化/生理作用

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.