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Merck
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主要文件

SAB1404611

Sigma-Aldrich

Monoclonal Anti-TNKS antibody produced in mouse

clone 1A3, purified immunoglobulin, buffered aqueous solution

别名:

PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.43

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

1A3, monoclonal

表单

buffered aqueous solution

分子量

antigen ~37.99 kDa

种属反应性

human

技术

capture ELISA: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

同位素/亚型

IgG2aκ

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... TNKS(8658)

一般描述

Mouse monoclonal antibody raised against a partial recombinant TNKS.
The gene TNKS (tankyrase) is mapped to human chromosome 8p23.1. It belongs to the PARP (poly (ADP-ribose) polymerase) family of proteins and is responsible for addition of poly (ADP-ribose) (PAR) to substrate proteins. The TNKS protein contains ankyrin repeats and a sterile α-motif (SAM).

免疫原

TNKS (NP_003738, 1017 a.a. ~ 1124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
TERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEE

生化/生理作用

TNKS (tankyrase) is a regulator of Wnt-signaling. It negatively regulates Axin1, thereby suppressing β-catenin degradation and causing hyperactivation of Wnt/β-catenin signaling. TNKS controls cell death and telomere length. It might also be associated with osteoarthritis. In murine lung cancer model, silencing of this gene reduces lung cancer cell growth. Application of TNKS inhibitor suppresses growth of hepatocellular carcinoma cells. Absence of TNKS activity helps in replication of human cytomegalovirus (HCMV).

外形

Solution in phosphate buffered saline, pH 7.4

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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