Merck
CN
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安全信息

T104

Sigma-Aldrich

Tropisetron

solid, ≥98% (HPLC)

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别名:
ICS-205,930, Navoban, endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-ol Indol-3-yl-carboxylate 单盐酸盐
经验公式（希尔记法）:
C17H20N2O2 · HCl
CAS号:
105826-92-4
分子量:
320.81
MDL编号:
MFCD00210221
PubChem化学物质编号:
24278133
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

solid

溶解性

H2O: >10 mg/mL

创始人

Novartis

储存温度

2-8°C

SMILES string

Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34

InChI

1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H

InChI key

XIEGSJAEZIGKSA-UHFFFAOYSA-N

Gene Information

human ... CHRNA3(1136) , CHRNA4(1137) , CHRNB2(1141) , CHRNB4(1143) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)
rat ... Chrna7(25302) , Drd2(24318) , Htr1a(24473) , Htr3a(79246)

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应用

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

生化/生理作用

Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.
3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT3 serotonin receptor antagonist.

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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E Beubler et al.
European journal of pharmacology, 248(2), 157-162 (1993-08-02)
The effects of cholera toxin and heat stable Escherichia coli (E. coli) enterotoxin on intestinal fluid secretion are commonly considered to be mediated by cyclic nucleotides. It was demonstrated recently, by using the 5-hydroxytryptamine (5-HT)2 receptor antagonist ketanserin and the
Li Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 846(1-2), 20-23 (2006-09-12)
A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected onto BDS-C(8) reversed column using a mixture of ammonium acetate (100 mM
N Yoshida et al.
The Journal of pharmacology and experimental therapeutics, 256(1), 272-278 (1991-01-01)
We studied the effect of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists on gastrointestinal (GI) motor activity in conscious dogs with force transducers implanted chronically. During the digestive state, GR38032F, BRL 43694 and ICS 205-930 did not affect GI motor activity at
Q Pei et al.
European journal of pharmacology, 230(1), 63-68 (1993-01-05)
The effects of three different 5HT3 receptor antagonists, granisetron, ICS 205-930 and ondansetron (0.01, 0.1 and 1 mg/kg, s.c.) were tested on changes in mesolimbic dopamine function produced by 1 mg/kg of morphine in the rat. Increases of in vivo
Orie Tomoyose et al.
Journal of pharmacological sciences, 126(2), 136-145 (2014-09-26)
Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, has been shown to exert analgesic effects in humans and laboratory animals. However, its effects on spinal nociceptive synaptic transmission have not been fully characterized. Here, whole-cell recordings were made from dorsal horn
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