T182

酪氨酸激酶抑制剂A9

Name: 酪氨酸激酶抑制剂A9
Brand: SIGMA

solid

别名:

Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile

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About This Item

经验公式（希尔记法）:

C₁₈H₂₂N₂O

CAS Number:

10537-47-0

分子量:

282.38

MDL编号:

MFCD00209853

UNSPSC代码:

51111800

PubChem化学物质编号:

24278069

NACRES:

NA.77

主要文件

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生物来源

synthetic (organic)

质量水平

100

方案

≥98% (HPLC)

表单

solid

颜色

yellow

mp

139-140 °C

溶解性

ethanol: 20 mg/mL
DMSO: <25 mg/mL
H₂O: insoluble

SMILES字符串

CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C

InChI

1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

InChI key

MZOPWQKISXCCTP-UHFFFAOYSA-N

基因信息

human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159)
mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

应用

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

生化/生理作用

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.