Merck
CN

T6277

Sigma-Aldrich

单克隆抗肌钙蛋白 T 小鼠抗

clone JLT-12, ascites fluid

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别名:
Anti-ANM, Anti-NEM5, Anti-STNT, Anti-TNT, Anti-TNTS
MDL编号:
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

ascites fluid

antibody product type

primary antibodies

克隆

JLT-12, monoclonal

包含

15 mM sodium azide

species reactivity

chicken, rat, bovine, rabbit

technique(s)

immunohistochemistry: suitable
western blot: 1:200 using rabbit total skeletal muscle extract

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

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此商品
T2928M4278MABT368
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

purified immunoglobulin

clone

JLT-12, monoclonal

clone

TH-16, monoclonal

clone

HM-1, monoclonal

clone

9C2.1, monoclonal

species reactivity

chicken, rat, bovine, rabbit

species reactivity

rat, sheep, human, monkey, bovine, rabbit, guinea pig

species reactivity

mouse, rat

species reactivity

mouse, rat

technique(s)

immunohistochemistry: suitable, western blot: 1:200 using rabbit total skeletal muscle extract

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable using native or SDS-denatured TH., microarray: suitable, western blot: 1:8,000 using extracts of cultured rat adrenal pheochromocytoma (PC12) cells.

technique(s)

immunohistochemistry (frozen sections): suitable, microarray: suitable, western blot: 1:500 using a fresh total rat brain extract or an enriched microtubule protein preparation

technique(s)

immunohistochemistry: suitable, western blot: suitable

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一般描述

单克隆抗肌钙蛋白T(小鼠 IgG1 同种型)来源于小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生的杂交瘤。
肌钙蛋白T是肌钙蛋白的重要亚基。肌钙蛋白T是一种逗号状或棒状蛋白,长度为185-205 Å。肌钙蛋白T位于肌动蛋白螺旋沟(helix groove)中,并延伸至肌动蛋白丝。血清肌钙蛋白T的寿命为120分钟。该蛋白的N-末端富含带负电荷的残基,C-末端富含带正电荷的残基。肌钙蛋白T中不均匀的电荷分布有助于其在生理盐浓度下的聚集。在人体内,心脏肌钙蛋白T有四种亚型,其中的三种在胚胎中表达,一种亚型在成年心脏中表达。

免疫原

来自兔骨骼肌的肌钙蛋白 T。

应用

小鼠抗肌钙蛋白 T 单克隆抗体可用于以下研究:
  • 免疫印迹分析。
  • 免疫细胞化学分析。
  • 免疫荧光。
小鼠抗肌钙蛋白 T 单克隆抗体可用于免疫染色。

生化/生理作用

肌钙蛋白T是肌钙蛋白的亚基,可促进肌钙蛋白与原肌球蛋白的结合。它在肌肉收缩中也起着至关重要的作用。心肌肌钙蛋白T是检测急性心肌梗死(MI)的潜在标志物。除了促进肌钙蛋白组分与肌动蛋白-原肌球蛋白丝的结合外,它还在调节肌动蛋白ATP酶活性方面发挥着重要作用。心肌肌钙蛋白T基因突变会导致肥厚型心肌病。

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Lori A Walker et al.
American journal of physiology. Heart and circulatory physiology, 301(3), H832-H840 (2011-05-31)
Right ventricular (RV) failure is one of the strongest predictors of mortality both in the presence of left ventricular decompensation and in the context of pulmonary vascular disease. Despite this, there is a limited understanding of the biochemical and mechanical
J C Moolman et al.
Journal of the American College of Cardiology, 29(3), 549-555 (1997-03-01)
This study was designed to verify initial observations of the clinical and prognostic features of hypertrophic cardiomyopathy caused by cardiac tropnin T gene mutations. The most common cause of sudden cardiac death in the young is hypertrophic cardiomyopathy, which is
Dynamics of the skeletal muscle secretome during myoblast differentiation
Henningsen J, et al.
Molecular and Cellular Proteomics, 9(11), 2482-2496 (2010)
Nicole Hellbach et al.
PloS one, 13(10), e0205589-e0205589 (2018-10-12)
Spinal muscular atrophy (SMA) is a severe genetic disorder that manifests in progressive neuromuscular degeneration. SMA originates from loss-of-function mutations of the SMN1 (Survival of Motor Neuron 1) gene. Recent evidence has implicated peripheral deficits, especially in skeletal muscle, as
H A Katus et al.
Circulation, 83(3), 902-912 (1991-03-01)
The present study was designed to evaluate the efficiency of a newly developed troponin T enzyme immunoassay for the detection of acute myocardial infarction. The study comprised 388 patients admitted with chest pain and suspected myocardial infarction and 101 patients

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